Association Between Helicobacter Pylori Infection and Long-term Outcome in Patients with Drug-eluting Stent Implantation
| Autor: | Bu-Xing Chen, Rui Wang, De-Zhao Wang, Lei-Lei Chen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Acute coronary syndrome medicine.medical_specialty medicine.medical_treatment Comorbidity Kaplan-Meier Estimate 030204 cardiovascular system & hematology Coronary Angiography Gastroenterology Article Helicobacter Infections 03 medical and health sciences 0302 clinical medicine Percutaneous Coronary Intervention Internal medicine medicine Humans Acute Coronary Syndrome Survival analysis Aged Proportional Hazards Models Multidisciplinary biology Helicobacter pylori business.industry Stent Percutaneous coronary intervention Drug-Eluting Stents Middle Aged medicine.disease biology.organism_classification Patient Outcome Assessment Drug-eluting stent 030211 gastroenterology & hepatology Female Upper gastrointestinal bleeding business Mace Follow-Up Studies |
| Zdroj: | Scientific Reports |
| ISSN: | 2045-2322 |
| Popis: | To investigate the relationship between Helicobacter pylori (Hp) infection and the long-term outcome in acute coronary syndrome (ACS) patients with drug-eluting stent (DES) implantation and so as to explore the significance of Hp eradication therapy in preventing major adverse cardiac events (MACE) and upper gastrointestinal bleeding (UGIB). 539 ACS patients with DES implantation from January 1, 2010 to December 31, 2012 were analyzed. All the patients were divided into two groups according to the result of 13C urea breath test. 253 patients with Hp infection were put into group A (Hp+), and 286 cases without Hp infection were put into group B (Hp−). Demographic data was collected and all patients went through biochemical indicators and other routine blood examinations. We explored the correlations of Hp infection with MACE and UGIB after 3 to 5 years of follow-up using survival analysis. Survival analysis showed that Hp infection was a predictor of MACE and UGI. Sub-group analysis showed that patients with Hp eradication therapy had no relationship with MACE but had a lower rate of UGIB than those without Hp eradication therapy. |
| Databáze: | OpenAIRE |
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