Synthesis, antitumor activity and structure-activity studies of novel pyridoxine-based bioisosteric analogs of estradiol

Autor:	Raylya R. Gabbasova, Denis Yu. Grishaev, Timur M. Bulatov, Yurii G. Shtyrlin, Olga Kataeva, Alfiya G. Iksanova, Mikhail V. Pugachev, Bashar Aljondi, Oksana V. Bondar, Zilya Yamaleeva, Tatyana V. Nikishova, Roman S. Pavelyev, Konstantin V. Balakin, Thang N.T. Nguyen
Rok vydání:	2020
Předmět:	Models Molecular Clinical Biochemistry In vitro cytotoxicity Pharmaceutical Science Tumor cells Antineoplastic Agents Crystallography X-Ray Biochemistry Structure-Activity Relationship Breast cancer Drug Discovery medicine Tumor Cells Cultured Humans MTT assay skin and connective tissue diseases Molecular Biology IC50 Cell Proliferation Antitumor activity Membrane Potential Mitochondrial Dose-Response Relationship Drug Estradiol Molecular Structure Drug discovery Chemistry Organic Chemistry Pyridoxine medicine.disease Molecular Medicine Drug Screening Assays Antitumor Reactive Oxygen Species medicine.drug
Zdroj:	Bioorganicmedicinal chemistry. 30
ISSN:	1464-3391
Popis:	A new efficient approach to the synthesis of 6-alkenyl substituted pyridoxine derivatives has been developed. A series of 31 novel alkenyl pyridoxine derivatives, stilbene-based bioisosteric analogs of estradiol, were synthesized. In vitro cytotoxicity of the obtained compounds against MCF-7 (ER+) breast cancer tumor cells was studied using the MTT assay. The most active compounds with IC50, MCF-7
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4b1a9bd1e4d5789f76e436050fbfbb0 https://pubmed.ncbi.nlm.nih.gov/33373820 Zobrazit plný text záznamu Full Text from ScienceDirect