POLYNUCLEOTIDE VACCINATION FOR CANCER-TREATMENT (REVIEW)
| Autor: | Aa Epenetos, Sj Bel, Ra Spooner |
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| Rok vydání: | 1995 |
| Předmět: | |
| Zdroj: | International Journal of Oncology. |
| ISSN: | 1791-2423 1019-6439 |
| DOI: | 10.3892/ijo.6.6.1203 |
| Popis: | Inoculation with pure naked DNA in the form of plasmids can stimulate both antibody and T-cell responses in vivo against plasmid-encoded proteins. Peptide products derived from cytosolic degradation of fragments of tumour-specific proteins, expressed de novo under the transcriptional control of strong mammalian or viral promoter/enhancer signals might gain access to the MHC Class I presentation pathway, mimicking the presentation of viral proteins in infected cells. Presentation as neo-antigens or surrogate antigens in this novel context may be a means of breaking immunological tolerance, and may lead to the generation of tumour-specific immune responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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