The use of the Gelot emulsifier in diclofenac sodium semi-solid preparations
| Autor: | Magdalena Piechota-Urbańska, Justyna Kołodziejska, Aneta Berner-Strzelczyk, Malgorzata Godlewska, Michał Krzysztof Kołodziejczyk, Agnieszka Jach |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Pharmacology
Chromatography business.industry Pharmacology toxicology emulsifiers lcsh:R lcsh:Medicine Pharmacy 02 engineering and technology General Medicine Diclofenac Sodium 021001 nanoscience & nanotechnology 030226 pharmacology & pharmacy Biochemistry 03 medical and health sciences pharmaceutical availability 0302 clinical medicine Medicine rheology 0210 nano-technology business diclofenac sodium Molecular Biology Semi solid |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 30, Iss 1, Pp 43-49 (2017) |
| ISSN: | 2300-6676 |
| Popis: | In topical formulations, the rheological parameters and pharmaceutical availability of many active agents have been improved by the addition of modern excipients. This translates into increased interest in the topical use of NSAIDs. The aim of this study was to create series of effective oil in water (O/W) diclofenac sodium cream formulations that differ in the applied fatty phase, utilizing Gelot TM64 (Gattefosse) (a modern non-ionic emulsifier). In the produced prescriptions, estimation was made of the effect of this on the rheological parameters and the pharmaceutical availability of the diclofenac sodium. Herein, the hydrophilic petrolatum-based cream demonstrated the highest rate of release of the active agent, as well as the best set of beneficial rheological parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
http://www.degruyter.com/view/j/cipms.2017.30.issue-1/cipms-2017-0010/cipms-2017-0010.xml?format=INT
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