Expression of neurotransmitter genes in motor regions of the dyskinetic rat after iminodipropionitrile
| Autor: | Th Lauterburg, J.A Fritschi, J.-M. Burgunder |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Dyskinesia Drug-Induced Glutamate decarboxylase Vasoactive intestinal peptide Oligonucleotides Neuropeptide Substantia nigra Striatum Dynorphin Biology Internal medicine Nitriles medicine Animals Rats Wistar Neurotransmitter Agents Tyrosine hydroxylase Histocytochemistry General Neuroscience Brain Rats Endocrinology Somatostatin nervous system Organ Specificity hormones hormone substitutes and hormone antagonists |
| Zdroj: | Neuroscience letters. 347(1) |
| ISSN: | 0304-3940 |
| Popis: | Rats treated with iminodipropionitrile develop a neurobehaviour syndrome with dyskinesia. Searching for the molecular correlates, we have examined the expression of selected genes involved in neurotransmission in motor regions using hybridization histochemistry. Frontal cortical and thalamic vasoactive intestinal peptide (VIP) expression, and striatal dynorphin, enkephalin (ENK) and substance P expression were increased. No change in cortical cholecystokinin (CCK), ENK, glutamic acid decarboxylase (GAD) and somatostatin (SRIF) expression, in striatal GAD, SRIF, nitric oxide synthase (NOS) and guanylate cyclase expression, and in thalamic CCK, GAD and thyrotropin-releasing hormone expression was found. NOS expression in the subthalamic nucleus as well as tyrosine hydroxylase, GAD and CCK expression in the substantia nigra were unchanged. These results confirm the involvement of striatal projection neurons in dyskinesia and suggest a novel role for VIP. |
| Databáze: | OpenAIRE |
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