The contribution of genetic variants of SLC2A1 gene in T2DM and T2DM-nephropathy: association study and meta-analysis

Autor: Stefanidis, I., Tziastoudi, M., Tsironi, E. E., Dardiotis, E., Tachmitzi, S. V., Fotiadou, A., Pissas, G., Kytoudis, K., Sounidaki, M., Ampatzis, G., Mertens, P. R., Liakopoulos, V., Eleftheriadis, T., Hadjigeorgiou, Georgios M., Santos, M., Zintzaras, E.
Přispěvatelé: Hadjigeorgiou, Georgios M. [0000-0001-5386-4273], Dardiotis, E. [0000-0003-2957-641X]
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
0301 basic medicine
Glucose transporter 1 (GLUT1)
Diabetic nephropathy
Type 2 diabetes
Critical Care and Intensive Care Medicine
Bioinformatics
lcsh:RC870-923
Nephropathy
03 medical and health sciences
Diabetes mellitus
Gene Frequency
Risk Factors
Slc2a1 gene
medicine
Humans
Diabetic Nephropathies
Genetic Predisposition to Disease
Gene
Alleles
Aged
genetic variants of SLC2A1
Aged
80 and over
Glucose Transporter Type 1
business.industry
glucose transporter 1 (GLUT1)
diabetic nephropathy
Glucose transporter
Genetic Variation
Genetic variants of SLC2A1
General Medicine
Middle Aged
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Logistic Models
030104 developmental biology
Diabetes Mellitus
Type 2
Nephrology
Case-Control Studies
Meta-analysis
Clinical Study
Female
business
Zdroj: Renal Failure, Vol 40, Iss 1, Pp 561-576 (2018)
Renal Failure
Ren Fail
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
ISSN: 1525-6049
Popis: An association study was conducted to investigate the relation between 14 variants of glucose transporter 1 gene (SLC2A1) and the risk of type 2 diabetes (T2DM) leading to nephropathy. We also performed a meta-analysis of 11 studies investigating association between diabetic nephropathy (DN) and SLC2A1 variants. The cohort included 197 cases (T2DM with nephropathy), 155 diseased controls (T2DM without nephropathy) and 246 healthy controls. The association of variants with disease progression was tested using generalized odds ratio (ORG). The risk of type 2 diabetes leading to nephropathy was estimated by the OR of additive and co-dominant models. The mode of inheritance was assessed using the degree of dominance index (h-index). We synthesized results of 11 studies examining association between 5 SLC2A1 variants and DN. ORG was used to assess the association between variants and DN using random effects models. Significant results were derived for co-dominant model of rs12407920 [OR = 2.01 (1.17–3.45)], rs841847 [OR = 1.73 (1.17–2.56)] and rs841853 [OR = 1.74 (1.18–2.55)] and for additive model of rs3729548 [OR = 0.52 (0.29–0.90)]. The mode of inheritance for rs12407920, rs841847 and rs841853 was ‘dominance of each minor allele’ and for rs3729548 ‘non-dominance’. Frequency of one haplotype (C-G-G-A-T-C-C-T-G-T-C-C-A-G) differed significantly between cases and healthy controls [p = .014]. Regarding meta-analysis, rs841853 contributed to an increased risk of DN [(ORG = 1.43 (1.09–1.88) ORG = 1.58 (1.01–2.48)] between diseased controls versus cases and healthy controls versus cases, respectively. Further studies confirm the association of rs12407920, rs841847, rs841853, as well as rs3729548 and the risk of T2DM leading to nephropathy. 40 1 561 576
Databáze: OpenAIRE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje