Long-term and multigeneration toxicity studies with cyclohexylamine hydrochloride
| Autor: | Bernard L. Oser, Stephen S. Sternberg, Eugene E. Vogin, George E. Cox, Steven Carson |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Dose media_common.quotation_subject Urinary Bladder Biology Toxicology Feed conversion ratio chemistry.chemical_compound Animal science Pregnancy Internal medicine medicine Animals Lactation Weaning Saccharin media_common Cyclohexylamines Behavior Animal Testicular atrophy Reproduction Body Weight Rats Inbred Strains Feeding Behavior Neoplasms Experimental Organ Size medicine.disease Teratology Rats Endocrinology chemistry Toxicity Female |
| Zdroj: | Toxicology. 6:47-65 |
| ISSN: | 0300-483X |
| DOI: | 10.1016/0300-483x(76)90007-x |
| Popis: | Cyclohexylamine (CHA), the metabolite of cyclamate produced in varying degree by gastrointestional microorganism, was subjected to a 2-year multi-generation feeding study in rats, at dosages of 15, 50, 100, and 150 mg/kr/d. Observations included growth, feed efficiency, clinical and hematological tests, reproduction, teratology, mortality and gross and microscocpic pathology. Rats from the litters of each generation from F 0 through F 4 were mated to produce the next succeeding generation. Those from the second litters of F 1 through F 4 also mated, half the dams being delivered by hysterotomy for teratological examination, while litters from the other half were raised to maturity. Except for some non-progressive growth retardation in the higher dosage groups, due to lower food consumption, the physical and clinical observations in the test groups fell substantially within normal limits and were not significantly different from the untreated controls. Reproduction rates were normal in all groups but at the higher dosages the size of the litters and their weaning weights were slightly reduced. At the 150 mg/kg level, histopathological examination revealed mucosal thickening of the bladder walls and evidence of renal calcificationl; however, no bladder tumors were seen, such as occured in the chronic feeding study in which rats recieved 2500 mg/kg of a cyclamate : saccharin (10 : 1) mixture. A significantly higher incidence of testicular atrophy, characteristic of aged rats, was observed in the F 0 group at the highest dosage level; however, these males continued to be fertile, in two cases up to 6 consecutive matings. |
| Databáze: | OpenAIRE |
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