ESBL expression and antibiotic resistance patterns in a hospital in Saudi Arabia: Do healthcare staff have the whole picture?
Autor: | Mohammed J. Alabdalslam, Salman A. Alsadiq, Ahmed S. Bueid, Hatem M. Alhani, Hebah A. Aldrazi, Fatimah A. Aldrazi, Ali A. Rabaan, Shahab A. Alsuliman |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Imipenem Klebsiella pneumoniae Tigecycline 0302 clinical medicine Surveys and Questionnaires polycyclic compounds Infection control 030212 general & internal medicine Child Aged 80 and over biology lcsh:Public aspects of medicine Enterobacteriaceae Infections Drug Resistance Microbial General Medicine Middle Aged Hospitals Infectious Diseases Child Preschool Female medicine.drug Adult medicine.medical_specialty Adolescent Attitude of Health Personnel Health Personnel 030106 microbiology Saudi Arabia Microbial Sensitivity Tests Meropenem beta-Lactamases lcsh:Infectious and parasitic diseases Young Adult 03 medical and health sciences Antibiotic resistance Enterobacteriaceae Internal medicine Escherichia coli medicine Humans lcsh:RC109-216 Proteus mirabilis Aged business.industry Infant Newborn Public Health Environmental and Occupational Health Infant lcsh:RA1-1270 biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses bacteria Morganella morganii business |
Zdroj: | Journal of Infection and Public Health, Vol 13, Iss 5, Pp 759-766 (2020) |
ISSN: | 1876-0341 |
Popis: | Background: We analyse the distribution of ESBL infections in Dammam Medical Complex, Eastern Province, Saudi Arabia with respect to patient demographics, wards, infection site, bacterial species, and antibiotic resistance. We also gauged hospital staff understanding of ESBLs, the procedures in place to identify, treat and infections containing. Methods: Hospital records from 2016 were analysed and 352 ESBL from several samples types were identified using VITEK® 2 system and by phenotypic confirmation using a disk diffusion test. HCWs attitudes and knowledge were assessed using a paper questionnaire. Results: The percentage of ESBL isolates were Klebsiella pneumoniae(n = 148; 42.1%) or Escherichia coli(n = 176; 50%), Proteus mirabilis(n = 7; 2%), Morganella morganii(n = 13; 3.7%), Enterobacter (n = 7; 2%) and Citrobacter freundii (n = 1; 0.3%). Overall tigecycline susceptibility was 82.2%, however P. mirabilis and M. morganii isolates were uniformly resistant and K. pneumoniae susceptibility levels were significantly lower than for E. coli in urine samples (72.3% v 100%; Chi square = 13.76, p = 0.0002); for blood samples there was also apparently higher resistance among K. pneumoniae isolates. Overall susceptibility to the carbapenems imipenem, meropenem and ertapenam was high. There were overall high levels of uncertainty among healthcare workers on hospital policies on reporting or prescribing with respect to ESBL-expressing infections. Conclusions: ESBL control strategies should consider variations among sample types, wards, and antibiotic resistance variability. There is a need to specifically address staff training and communication procedures for infection prevention and control with respect to ESBLs. Keywords: ESBL, Saudi Arabia, Enterobacteriaceae, Antibiotic resistance, Healthcare workers |
Databáze: | OpenAIRE |
Externí odkaz: |