Development and validation of a bioanalytical method for five antidepressants in human milk by LC–MS
| Autor: | Felipe Bianchini D'Avila, Fernanda Rodrigues Salazar, Ana Maria Bergold, Marcella Herbstrith de Oliveira, Pamela C.L. Ferreira |
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| Rok vydání: | 2016 |
| Předmět: |
Postpartum depression
medicine.medical_specialty Clinical Biochemistry Breastfeeding Pharmaceutical Science Pharmacology Breast milk Citalopram 030226 pharmacology & pharmacy 01 natural sciences Mass Spectrometry Analytical Chemistry Depression Postpartum 03 medical and health sciences 0302 clinical medicine Internal medicine Lactation Drug Discovery medicine Humans Technology Pharmaceutical Spectroscopy Fluoxetine Sertraline Milk Human Chemistry 010401 analytical chemistry Infant medicine.disease Antidepressive Agents 0104 chemical sciences Breast Feeding medicine.anatomical_structure Biological Assay Female Postpartum period Chromatography Liquid medicine.drug |
| Zdroj: | Journal of Pharmaceutical and Biomedical Analysis. 129:502-508 |
| ISSN: | 0731-7085 |
| Popis: | The use of medications during lactation is a common practice; however, pharmacological treatments impose serious doubts to both professionals and nursing mothers regarding the safety of drugs used during this period. Most of drugs are excreted in breast milk and there is great variability in the amount of analytes that can be received by the infant. Dilemmas about breastfeeding arise most commonly in relation to postpartum depression. Depression is a major clinical problem during the postpartum period and the vulnerability to onset or recurrence of depressive symptoms increases the possibility of psychotropic drug use during lactation. Selective inhibitors of serotonin reuptake are commonly prescribed for the treatment of depressive disorders, including fluoxetine, sertraline, citalopram, and paroxetine. A validated bioanalytical method using liquid chromatography coupled to mass spectrometry was developed and validated for determination of antidepressants in human milk following protein precipation. The bioanalytical method was successfully applied to assess milk samples from nursing mothers. From found concentrations, infant absolute (4.36–12.26 μg/kg/day) and relative dose (0.60–2.90%,) were estimated and low values were obtained indicating safe use during laction. However, other factors such as complemantary feeding and hepatic or renal disorders in the infant should be considered. |
| Databáze: | OpenAIRE |
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