Anterior segment ischemia after laser for retinopathy of prematurity previously treated with antivascular endothelial growth factor
| Autor: | Erick D. Bothun, Sasha A. Mansukhani, Brian G. Mohney, Samantha D. Sagaser, Polly A. Quiram, Danny A. Mammo, Clara M. Castillejo Becerra |
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| Rok vydání: | 2021 |
| Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty genetic structures Birth weight Angiogenesis Inhibitors Gestational Age Endothelial Growth Factors law.invention 03 medical and health sciences 0302 clinical medicine Anterior Segment Ischemia Cataracts Ischemia law Ophthalmology medicine Humans Retinopathy of Prematurity Retrospective Studies Laser Coagulation business.industry Lasers Medical record Infant Newborn Infant Gestational age Retinopathy of prematurity medicine.disease Laser eye diseases Bevacizumab Intravitreal Injections Pediatrics Perinatology and Child Health 030221 ophthalmology & optometry Previously treated business |
| Zdroj: | Journal of American Association for Pediatric Ophthalmology and Strabismus. 25:155.e1-155.e5 |
| ISSN: | 1091-8531 |
| DOI: | 10.1016/j.jaapos.2021.01.007 |
| Popis: | To assess the risk of vision-threatening anterior segment ischemia (ASI) among retinopathy of prematurity (ROP) patients treated with anti-VEGF followed by laser photocoagulation.The medical records of all infants treated for threshold ROP with laser photocoagulation with and without prior anti-VEGF injections from January 1, 2002, through December 2018 at Mayo Clinic were retrospectively reviewed for the prevalence of vision-threatening ASI.A total of 241 eyes of 122 infants were included. Mean gestational age was 25.1 weeks (range, 22.9-28.7); mean birth weight was 687.6 g (range, 360-1310 g). Of the 54 eyes (27 patients) treated with anti-VEGF prior to laser, 4 developed ASI (including corneal edema, cataracts, and choroidal effusion) compared with 2 of the 187 eyes (95 patients) treated with laser therapy alone (P = 0.008). Infants receiving both anti-VEGF and laser had a younger gestational age at birth (24.5 vs 25.3 weeks; P 0.001) and lower birth weight (591.4 g vs 715.0 g; P 0.001) than those who received laser alone. In multivariate analysis, early gestational age at birth was associated with development of ASI (P = 0.03); the association with anti-VEGF treatment (P = 0.07) fell short of statistical significance.The prevalence of vision-threatening ASI was higher among infants treated with intravitreal anti-VEGF followed by laser compared to those treated with laser alone. Further investigation is warranted to confirm this finding and identify potential factors for decreasing the risk of ASI. |
| Databáze: | OpenAIRE |
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