Can accelerated transcranial direct current stimulation improve memory functions? An experimental, placebo-controlled study

Autor: Per M. Aslaksen, Ingrid Daae Rasmussen, Ida Karine Larsen Wiik, Ole Kristian Grønli, Martin Bystad, Benedicte Haug Storø, Lene Nordvang, Nina Gundersen
Rok vydání: 2020
Předmět:
0301 basic medicine
Nervous system
medicine.medical_specialty
medicine.medical_treatment
Trail Making Test
Placebo-controlled study
Cognitive enhancer
Audiology
Placebo
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Nevrologi: 752
Learning and memory
03 medical and health sciences
0302 clinical medicine
Cognition
Memory
Neuropsychology
Medicine
lcsh:Social sciences (General)
lcsh:Science (General)
Recognition memory
Multidisciplinary
Transcranial direct-current stimulation
business.industry
Neuromodulation
Cognitive neuroscience
Executive functions
030104 developmental biology
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Neurology: 752
lcsh:H1-99
Transcranial direct current stimulation
Verbal memory
business
030217 neurology & neurosurgery
lcsh:Q1-390
Research Article
Neuroscience
Zdroj: Heliyon
Heliyon, Vol 6, Iss 10, Pp e05132-(2020)
ISSN: 2405-8440
Popis: The aim of this study was to investigate whether transcranial Direct Current Stimulation (tDCS) could improve verbal memory functions in healthy old and younger participants. We hypothesized that active tDCS led to significantly improved memory function, compared to placebo tDCS. Forty healthy participants (20 old and 20 younger participants) were included in the study. We applied a novel stimulation protocol, where six sessions of anodal tDCS were administrated during two consecutive days. Each tDCS session lasted 30 min. The current intensity was 2mA and the stimulation area was the left temporal lobe at T3 in the 10–20 EEG system. Immediate recall, delayed recall and recognition memory were assessed with California Verbal Learning Test II (CVLT-II) and executive functions were assessed with the Trail Making Test (TMT) before the first tDCS session and after the last tDCS session. Half of the participants received placebo tDCS, whereas the other half received active tDCS. We did not reveal any significant differences between active and placebo tDCS in memory functions. However, there was a significant difference between active and placebo tDCS in executive function measured by the Trail Making Test (TMT). This experimental study failed to reveal significant differences between active and placebo accelerated tDCS for verbal memory functions. However, accelerated tDCS was found to be well-tolerated in this study.
Neuroscience; Cognitive neuroscience; Nervous system; Cognition; Learning and memory; Memory; Transcranial direct current stimulation; Neuropsychology; Neuromodulation; Cognitive enhancer.
Databáze: OpenAIRE
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