Investigation of Total Antioxidant Status and Total Oxidant Status with Seizure Types in Patients with Epilepsy

Autor: Bahadır Taşlıdere, Ferda Uslu, Ertan Sönmez, Şahabettin Selek
Přispěvatelé: TAŞLIDERE, BAHADIR, USLU, FERDA, SÖNMEZ, ERTAN, SELEK, ŞAHABETTİN, SÖNMEZ, Ertan, USLU, Ferda
Rok vydání: 2022
Předmět:
Zdroj: Cyprus Journal of Medical Sciences. 7:609-613
ISSN: 2536-507X
2149-7893
Popis: BACKGROUND/AIMS: As epilepsy is a complex disease group, it is difficult to diagnose and classify. Oxidative stress plays a vital role in the pathogenesis of epilepsy. This study investigated the total oxidant/antioxidant status levels in patients with focal onset and generalized onset seizures. The results we obtained may help find the etiological cause in patients with seizure complaints and may guide their treatment. In addition, knowing the seizure type of the patient can give an idea about the prognosis of their disease.MATERIALS AND METHODS: The total number of patients included in this prospective study was 58. There were also 57 people in a control group. The patients were classified according to their type of seizure: focal or generalized onset. The serum oxidative stress index (OSI) and total oxidant/antioxidant status values of all patients and control group members were measured. The patients (focal/generalized groups) and control group members were compared.RESULTS: This prospective study was completed with 58 eligible patients who met the inclusion criteria. There were 57 people in the control group. Total oxidant status (TOS) and OSI levels were higher in the seizure groups compared to the control group (p
Databáze: OpenAIRE