Association of a common genetic variant (insertion/deletion) in ACE gene with prostate cancer susceptibility in a Tunisian population
| Autor: | S. Zaghbib, Marouene Chakroun, Mohamed Chebil, Rim Jenni, Amine Derouiche, Rahma Said, Feryel Ammous, Sami Boussetta, Slah Ouerhani, S. Zouari |
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| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Oncology Male medicine.medical_specialty Tunisia Clinical Biochemistry Peptidyl-Dipeptidase A law.invention Metastasis polymorphism Prostate cancer INDEL Mutation law Polymorphism (computer science) Alu Elements Internal medicine Epidemiology Genotype Immunology and Allergy Medicine Humans Genetic Predisposition to Disease Allele Polymerase chain reaction Research Articles Aged Aged 80 and over Polymorphism Genetic business.industry Biochemistry (medical) Public Health Environmental and Occupational Health Prostatic Neoplasms Hematology Middle Aged medicine.disease North Africa prostate cancer Medical Laboratory Technology genomic DNA angiotensin conversion enzymes Case-Control Studies business Research Article Alu repeat sequence |
| Zdroj: | Journal of Clinical Laboratory Analysis |
| ISSN: | 1098-2825 |
| Popis: | Background Angiotensin‐converting enzyme (ACE) plays a pivotal role in several pathologies including cancers. The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. We aimed to investigate for the first time, to our Knowledge, in North Africa the potential relationship between ACE I/D polymorphism with PC susceptibility and clinical outcomes of PC patients. Methods This case‐control study included 143 healthy individuals and 124 patients diagnosed with PC. Using genomic DNA, the samples were genotyped for ACE I/D polymorphism by polymerase chain reaction (PCR). Results We found that The D allele is significantly associated with an increased risk of PC and D/D + D/I genotypes were at 3 times increased risk of PC ([p = 0.005], OR = 2.95, IC 95% = 1.26–7.09) compared with I/I genotype (p = 0.003, OR = 0.3, IC 95% = 0.12–0.74). We observed an association between D/D and D/I genotypes with advanced age (≥70 years) (p = 0.014; r 2 = 0.22). Furthermore, there is a significant prediction of advanced Gleason score ≥8 based on epidemiological parameters and ACE genotype (p = 0.000; R2 = 0.349), although no significant association was observed with stage and metastasis. Conclusion The ACE I/D polymorphism is likely to predispose to PC and could play a role in PC progression and aggressiveness. The association of insertion/deletion (I/D) polymorphism of the ACE gene with prostate cancer (PC) risk remains controversial. The ACE SNP rs 4646994 is likely to predispose to PC and aggressiveness in Tunisia population. This study provides valuable information for the diagnosis and prognosis of the risk of PC disease. |
| Databáze: | OpenAIRE |
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