Enriched Expression of Serotonin 1B and 2A Receptor Genes in Macaque Visual Cortex and their Bidirectional Modulatory Effects on Neuronal Responses

Autor:	Toru Takahata, Tsutomu Hashikawa, Hiromichi Sato, Hironobu Osaki, Tomoyuki Naito, Ayako Ishikawa, Shiro Tochitani, Akiya Watakabe, Osamu Sadakane, Shin-ichiro Hara, Satoshi Shimegi, Hiroshi Sakamoto, Takafumi Akasaki, Yusuke Komatsu, Masahiro Okamoto, Tetsuo Yamamori, Noriyuki Higo
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	Agonist medicine.drug_class Cognitive Neuroscience 5-HT Action Potentials Gene Expression In situ hybridization Biology Serotonergic primate Macaque Cellular and Molecular Neuroscience biology.animal Chlorocebus aethiops medicine Animals Receptor Serotonin 5-HT2A visual cortex Receptor In Situ Hybridization Neurons Reverse Transcriptase Polymerase Chain Reaction Articles monocular deprivation activity-dependent Serotonin Receptor Agonists Electrophysiology Visual cortex medicine.anatomical_structure Receptor Serotonin 5-HT1B Macaca Serotonin Neuroscience area-specific Photic Stimulation
Zdroj:	Cerebral Cortex (New York, NY)
ISSN:	1460-2199 1047-3211
Popis:	To study the molecular mechanism how cortical areas are specialized in adult primates, we searched for area-specific genes in macaque monkeys and found striking enrichment of serotonin (5-hydroxytryptamine, 5-HT) 1B receptor mRNA, and to a lesser extent, of 5-HT2A receptor mRNA, in the primary visual area (V1). In situ hybridization analyses revealed that both mRNA species were highly concentrated in the geniculorecipient layers IVA and IVC, where they were coexpressed in the same neurons. Monocular inactivation by tetrodotoxin injection resulted in a strong and rapid (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a11db61a4196ebc6492175cb355137 http://europepmc.org/articles/PMC2705701 Zobrazit plný text záznamu