Hepatitis B core antigen-based vaccine demonstrates cross-neutralization against heterologous North American Porcine Reproductive and Respiratory Syndrome Virus (PRRSV-2) strains
| Autor: | Amy Rizzo, Chenming Zhang, Yi Lu, Qian M. Cao, Xiang-Jin Meng, Frank Gillam |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Swine
viruses animal diseases Porcine Reproductive and Respiratory Syndrome Heterologous Antibodies Viral Epitope Virus Epitopes Mice Antigen Virology Animals Hepatitis B Vaccines Vaccines Virus-Like Particle Mice Inbred BALB C biology Genetic heterogeneity virus diseases respiratory system Porcine reproductive and respiratory syndrome virus biology.organism_classification Antibodies Neutralizing Hepatitis B Core Antigens HBcAg Female Hepatitis b core |
| Zdroj: | Journal of Virological Methods. 285:113945 |
| ISSN: | 0166-0934 |
| Popis: | The U.S. swine industry have been bearing the financial impact of Porcine Reproductive and Respiratory Syndrome (PRRS) for decades. Absent of a safe and efficacious vaccine to combat PRRS virus's genetic heterogeneity, it remains a costly disease on pig farms across the country. We have developed virus-like-particle (VLP) based vaccines that incorporate 4 PRRSV epitopes in the hepatitis B core antigen (HBcAg) backbone. Administration of the vaccines in female BALB/C mice resulted in extremely significant PRRSV epitope specific antibody response. One vaccine candidate GP3-4 was able to mount a significant viral neutralizing response against both parental PRRSV strain VR2385 and heterologous PRRSV strain NADC20, showing a promising potential for cross-protection against PRRSV. |
| Databáze: | OpenAIRE |
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