Thyroid antigen-antibody nephritis: possible involvement of fucosyl-GM1 as the antigen
| Autor: | Teruo Kitagawa, Kyoji Akashi, Kazunari Iidaka, Masao Iwamori, Yumio Kikkawa, Mikio Matsuura, Toshiaki Serisawa, Takimoto T, Zenshirou Inage |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.medical_treatment Fluorescent Antibody Technique Antigen-Antibody Complex G(M1) Ganglioside Hyperthyroidism Endocrinology Antigen Internal medicine medicine Humans Child Nephritis biology medicine.diagnostic_test business.industry Thyroid General Engineering Glomerulonephritis medicine.disease Immune complex medicine.anatomical_structure biology.protein Thyroglobulin Female Renal biopsy Antibody business |
| Zdroj: | Endocrinologia japonica. 34(4) |
| ISSN: | 0013-7219 |
| Popis: | Hyperthyroidism, microscopic hematuria, and proteinuria developed in an 11-year-old girl. Proteinuria decreased during treatment of hyperthyroidism with an antithyroid drug. On admission, serum anti-thyroglobulin antibody, antimicrosomal antibody, and immune complex were present. The thyrotropin binding inhibitory immunoglobulin (TBII) level was low. On the other hand, an antibody to the ganglioside component (fucosyl-GM1) was detected by an enzyme linked immunosolvent assay (ELISA).interstitial fibrosis. A renal biopsy specimen showed marked proliferation of A thyroid biopsy specimen showed massive lymphocytic infiltration and mesangial cells and increased mesangial matrix with focal segmental capillary wall abnormality. Electron microscopec studies demonstrated mild paramesangial dense deposits.A thyroid biopsy specimen showed massive lymphocytic infiltration and interstitial fibrosis. A renal biopsy specimen showed marked proliferation of mesangial cells and increased mesangial matrix with focal segmental capillary wall abnormality. Electron microscopec studies demonstrated mild paramesangialdense deposits.By indirect immunofluorescence, granular glomerular basement membraneand mesangial staining were not detected with rabbit antibody to thyroglobulin, but were detected with rabbit antibody to fucosyl GM1. Fucosyl GM1 was also seen along the basilar aspect of the thyroid follicular epithelial cells.These observation suggests the development of glomerulonephritis mediated by thyroid antigen, particularly ganglioside component. |
| Databáze: | OpenAIRE |
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