Decreased expression of STAT5A predicts poor prognosis in osteosarcoma
| Autor: | Youwei Fu, Zong-Hui Guo, Yin Tang, Junjie Wang |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Adolescent Down-Regulation Bone Neoplasms Kaplan-Meier Estimate Logistic regression Malignancy Pathology and Forensic Medicine STAT5A Metastasis Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine Biomarkers Tumor STAT5 Transcription Factor medicine Humans Child Survival analysis STAT5 Proportional Hazards Models Osteosarcoma biology business.industry Proportional hazards model Tumor Suppressor Proteins food and beverages Cell Biology Prognosis medicine.disease 030104 developmental biology Child Preschool 030220 oncology & carcinogenesis biology.protein Female business |
| Zdroj: | Pathology - Research and Practice. 215:519-524 |
| ISSN: | 0344-0338 |
| Popis: | Signal transducer and activator of transcription 5 (STAT5) plays a key role in the malignancy of many tumors and has been identified as a therapeutic target. However, the role of STAT5A in osteosarcoma is still unclear.98 osteosarcoma patients were obtain from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET). The relationship between STAT5A and clinical features was analyzed using the Wilcoxon signed-rank test and logistic regression. Kaplan-Meier method, univariate and multivariate Cox regression analyses were performed to assess the prognostic value in event-free survival (EFS) and overall survival (OS). Gene Set Enrichment Analysis (GSEA) was performed.STAT5A low expression was not linked to age, gender, tumor site, surgical approach, tumor region, histologic response, and metastasis, but was correlated with progression (OR = 5.2, P = 0.012). Kaplan-Meier survival curve showed that patients with STAT5A low expression had worse EFS and OS than those with STAT5A high expression (P 0.01). Furthermore, the multivariate analysis revealed STAT5A was an independent prognostic factor for poor OS (HR = 3.29, P = 0.0408)) and EFS (HR = 7.29, P = 0.0025). GSEA showed that the complemen, metabolism, apoptosis, interferon-gamma response, inflammatory response, Notch, Kras, reactive oxygen species, VEGF, IL-6/JAK/STAT3, IL-2/Stat5, B-cell receptor, and p53 pathways were significantly associated with the STAT5A gene.STAT5A may be a novel prognostic factor for osteosarcoma and may act as a molecular target in the treatment of osteosarcoma. |
| Databáze: | OpenAIRE |
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