Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area
| Autor: | Pete Smith, Kassim S. Alawi, Lorenzo Savioli, Hababu M. Chwaya, Andrew Hall, Marco Albonico, Elena Ercole |
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| Rok vydání: | 1995 |
| Předmět: |
Time Factors
Mebendazole Helminthiasis Physiology Albendazole Tanzania Sampling Studies Feces Hookworm Infections Recurrence medicine Humans Trichuriasis Intestinal Diseases Parasitic Child Parasite Egg Count Hookworm infection Ascariasis Hookworm vaccine biology Ascaris Antinematodal Agents Public Health Environmental and Occupational Health General Medicine biology.organism_classification medicine.disease Treatment Outcome Infectious Diseases Immunology Trichuris trichiura Parasitology Ascaris lumbricoides medicine.drug |
| Zdroj: | Transactions of the Royal Society of Tropical Medicine and Hygiene. 89:538-541 |
| ISSN: | 0035-9203 |
| DOI: | 10.1016/0035-9203(95)90101-9 |
| Popis: | The comparative efficacy of albendazole and mebendazole in the treatment of intestinal nematode infections were compared 3 weeks after treatment in a randomized trial among schoolchildren on Pemba Island, Tanzania. Egg counts were compared 3 weeks, 4 months and 6 months after treatment of 731 children seen on each occasion. Differences in the efficacies were apparent with some nematodes 21 d after treatment, but these were no longer apparent 4 months after treatment, and by 6 months intensities of infection were similar to pre-treatment levels. These findings suggest that treatment of schoolchildren every 4 months may be necessary in this highly endemic area in order to have an impact on the intensity of intestinal nematode infections sufficient to be likely to reduce morbidity. |
| Databáze: | OpenAIRE |
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