The solution structures of epidermal growth factor and transforming growth factor alpha
| Autor: | Martin Baron, Timothy S. Harvey, Robert M. Cooke, Iain D. Campbell, Michael J. Tappin |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
TGF alpha
medicine.medical_specialty Magnetic Resonance Spectroscopy Extracellular proteins Epidermal Growth Factor Human epidermal growth factor Protein Conformation Molecular Sequence Data Mutagenesis (molecular biology technique) General Medicine Biology Transforming Growth Factor alpha Solution structure Cell biology Solutions Endocrinology Transforming growth factor beta 3 Epidermal growth factor Internal medicine medicine Animals Humans Amino Acid Sequence General Agricultural and Biological Sciences Transforming growth factor |
| Zdroj: | Progress in growth factor research. 1(1) |
| ISSN: | 0955-2235 |
| Popis: | The structures of human epidermal growth factor (EGF) and human transforming growth factor alpha (TGF alpha) have been determined in solution using nuclear magnetic resonance techniques. The features of each structure are described and similarities and differences between them are discussed. The structures are combined with information from sequence homologies to produce a model of the receptor-recognition sites of EGF and TGF alpha, which can be tested in a site-directed mutagenesis programme. The model assists in explaining previous observations of sequence-activity relationships. The TGF alpha and EGF structures also serve as models for homologous modules in other extracellular proteins. |
| Databáze: | OpenAIRE |
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