Comparison of ciprofloxacin and ceftriaxone as single-dose therapy for uncomplicated gonorrhea in women
| Autor: | T F Mroczkowski, Robert B. Jones, J J Haag, David H. Martin, E W Hook rd, G A Bolan, T M Neumann, R Echols |
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| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent medicine.drug_class Gonorrhea Antibiotics Microbial Sensitivity Tests medicine.disease_cause Injections Intramuscular Gastroenterology Drug Administration Schedule Double-Blind Method Ciprofloxacin Internal medicine medicine Humans Pharmacology (medical) Prospective Studies Antibacterial agent Pharmacology biology business.industry Ceftriaxone Middle Aged medicine.disease biology.organism_classification Neisseria gonorrhoeae Surgery Penicillin Infectious Diseases Female Neisseriaceae business Follow-Up Studies Research Article medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 37:1670-1673 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Although women bear the brunt of gonococcal infection-related morbidity, few large studies of gonorrhea treatment in women have been conducted. In a multicenter, double-blind, placebo-controlled trial, 181 evaluable women with uncomplicated gonorrhea were treated with ciprofloxacin (250 mg orally; 94 women) or ceftriaxone (250 mg intramuscularly; 87 women). Twenty-four percent of the participants were infected with antibiotic-resistant Neisseria gonorrhoeae. Cervical gonorrhea was cured in 100% (93 of 93) of the women treated with ciprofloxacin and 99% (83 of 84) receiving ceftriaxone. All pharyngeal (n = 5) or rectal (n = 20) infections treated with ciprofloxacin were cured, as were ceftriaxone-treated patients with pharyngeal (n = 6) or rectal (n = 21) infection. Geometric mean MICs (range) for 248 pretreatment isolates were: penicillin, 0.28 (0.015 to 8.0); tetracycline, 0.46 (0.06 to 4); ciprofloxacin, 0.003 (0.002 to 0.015); and ceftriaxone, 0.004 (0.001 to 0.125) microgram/ml. Both drugs were well tolerated. Despite the high prevalence of antibiotic-resistant gonococci in these populations, 250 mg of oral ciprofloxacin was as effective as an injection of ceftriaxone. |
| Databáze: | OpenAIRE |
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