Expression of adhesion proteins (E-cadherin and β-catenin) and cell proliferation (Ki-67) at the invasive tumor front in conventional oral squamous cell and basaloid squamous cell carcinomas
| Autor: | Rita de Cássia Gonçalves Alencar, Allisson Filipe Lopes Martins, Marília Oliveira Morais, Cláudio Rodrigues Leles, Mariana Quirino Silveira Soares, Aline Carvalho Batista, Elismauro Francisco Mendonça, Carlos Henrique Pereira |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Proliferation index Cell Biology 03 medical and health sciences 0302 clinical medicine Risk Factors medicine Humans Basaloid Squamous Cell Carcinoma General Dentistry beta Catenin Cell Proliferation Mouth neoplasm Cadherin Cell adhesion molecule 030206 dentistry Cell Biology General Medicine Middle Aged Cadherins Immunohistochemistry Survival Analysis stomatognathic diseases Ki-67 Antigen medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Catenin Ki-67 Carcinoma Squamous Cell biology.protein Female Mouth Neoplasms |
| Zdroj: | Archives of Oral Biology. 61:8-15 |
| ISSN: | 0003-9969 |
| DOI: | 10.1016/j.archoralbio.2015.10.003 |
| Popis: | Investigate, on a comparative basis, the expression of the adhesion molecules E-cadherin (E-cad), β-catenin (β-cat) and the proliferation index (Ki-67) at the invasive tumor front (ITF) in squamous cell carcinoma (SCC) and basaloid squamous cell carcinoma (BSCC).Thirty-five SCC and 16 BSCC cases were evaluated by immunohistochemistry. Clinicopathological and survival data were also evaluated and compared.There was a low expression of E-cad in the cytoplasmic membrane (p=0.50) as well as in the nucleus (p=0.31) for both SCC and BSCC. A high expression of E-cad was seen in the cytoplasm for the SCC group (80%) when compared to the BSCC group (25%) (p0.01). The expression of β-cat was low in the cytoplasmic membrane and high in the cytoplasm in both SCC and BSCC groups. Both types of carcinoma presented low expressions of β-cat in the nucleus (p=0.03). The Ki-67 expression was low irrespective of tumor variant. The high expression of E-cad in the cytoplasm was associated with T3/T4 tumors (p=0.04) in the SCC group and there was no significant association of E-cad, β-cat, Ki-67 with the other clinical variables. In terms of disease-free survival and overall survival, there were no significant differences between SCC and BSCC.The E-cad-β-cat system was found to be dysregulated in both oral SCC and oral BSCC. The Ki-67 cell proliferation index was extremely low in the cases investigated and consequently had no prognostic value. |
| Databáze: | OpenAIRE |
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