Impact of Early Acute Kidney Injury on Management and Outcome in Patients With Acute Respiratory Distress Syndrome: A Secondary Analysis of a Multicenter Observational Study
| Autor: | Hernan Aguirre-Bermeo, Giacomo Bellani, Gustavo A. Plotnikow, Philippe Michel, Gyorgy Frendl, Niall Ferguson, Ewan Goligher, Lars Hedlund, Rodrigo Biondi, Alexey Gritsan, Serena Knowles, Candelaria De Haro, Olegs Sabelnikovs, Jonathan Chelly, Riccardo Colombo, Fabiana Madotto, Aroa Gomez Brey, Vivek Kakar, Bairbre McNicholas, Joana Berger-Estilita, Alistair Nichol, Jean-Daniel Chiche, Anatole Harrois, Christopher Tainter, Matthew Griffin, Evgeny Grigoryev, Dorothy Breen, Alessandro Protti, Necmettin Unal, Ednan Bajwa, Artigas Antonio, Ceri Battle, ANTONIO PELLICER, Christina Whitehead, Jon Laake, Raúl De Pablo Sánchez, Nicolas TERZI, Emanuele Rezoagli |
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| Přispěvatelé: | AII - Inflammatory diseases, Intensive Care Medicine, ACS - Diabetes & metabolism, ACS - Pulmonary hypertension & thrombosis, ACS - Microcirculation, McNicholas BA, Rezoagli E, Pham T, Madotto F, Guiard E, Fanelli V, Bellani G, Griffin MD, Ranieri M, Laffey JG, ESICM Trials Group and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators., UCL - SSS/IREC/MEDA - Pôle de médecine aiguë, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (SLuc) Service de soins intensifs, UCL - (MGD) Services des soins intensifs, McNicholas, Bairbre A, Rezoagli, Emanuele, Pham, Tài, Madotto, Fabiana, Guiard, Elsa, Fanelli, Vito, Bellani, Giacomo, Griffin, Matthew D, Ranieri, Marco, Laffey, John G, Pesenti A, Laffey JG, ESICM Trials Group and the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) Investigators, Giarratano A, Cortegiani A, Mcnicholas, B, Rezoagli, E, Pham, T, Madotto, F, Guiard, E, Fanelli, V, Bellani, G, Griffin, M, Ranieri, M, Laffey, J |
| Rok vydání: | 2019 |
| Předmět: |
Male
ARDS medicine.medical_treatment Comorbidity Critical Care and Intensive Care Medicine Severity of Illness Index chemistry.chemical_compound 0302 clinical medicine acute kindey faliure Risk Factors Odds Ratio 80 and over Hospital Mortality Prospective Studies Aged 80 and over Respiratory Distress Syndrome Respiration Acute kidney injury Middle Aged acute kidney injury acute respiratory distress syndrome invasive mechanical ventilation mortality renal replacement therapy Intensive Care Units acute kidney injury Creatinine Artificial Female Glomerular Filtration Rate Adult invasive mechanical ventilation renal replacement therapy medicine.medical_specialty Socio-culturale Renal function ard 03 medical and health sciences Internal medicine Settore MED/41 - ANESTESIOLOGIA Severity of illness medicine Humans acute kidney injury acute respiratory distress syndrome Renal replacement therapy Aged business.industry 030208 emergency & critical care medicine Carbon Dioxide acute respiratory distress syndrome medicine.disease Respiration Artificial mortality lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] 030228 respiratory system chemistry Respiratory failure business Respiratory minute volume |
| Zdroj: | Critical Care Medicine, 47, 9, pp. 1216-1225 Critical care medicine, 47(9), 1216-1225. Lippincott Williams and Wilkins Critical care medicine, Vol. 47, no.9, p. 1216-1225 (2019) Critical Care Medicine, 47, 1216-1225 Europe PubMed Central |
| ISSN: | 0090-3493 1216-1225 |
| Popis: | Contains fulltext : 208648.pdf (Publisher’s version ) (Closed access) OBJECTIVES: To understand the impact of mild-moderate and severe acute kidney injury in patients with acute respiratory distress syndrome. DESIGN: Secondary analysis of the "Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure", an international prospective cohort study of patients with severe respiratory failure. SETTING: Four-hundred fifty-nine ICUs from 50 countries across five continents. SUBJECTS: Patients with a glomerular filtration rate greater than 60 mL/min/1.73 m prior to admission who fulfilled criteria of acute respiratory distress syndrome on day 1 and day 2 of acute hypoxemic respiratory failure. INTERVENTIONS: Patients were categorized based on worst serum creatinine or urine output into: 1) no acute kidney injury (serum creatinine < 132 micromol/L or urine output >/= 0.5 mL/kg/hr), 2) mild-moderate acute kidney injury (serum creatinine 132-354 micromol/L or minimum urine output between 0.3 and 0.5mL/kg/hr), or 3) severe acute kidney injury (serum creatinine > 354 micromol/L or renal replacement therapy or minimum urine output < 0.3 mL/kg/hr). MEASUREMENTS AND MAIN RESULTS: The primary outcome was hospital mortality, whereas secondary outcomes included prevalence of acute kidney injury and characterization of acute respiratory distress syndrome risk factors and illness severity patterns, in patients with acute kidney injury versus no acute kidney injury. One-thousand nine-hundred seventy-four patients met inclusion criteria: 1,209 (61%) with no acute kidney injury, 468 (24%) with mild-moderate acute kidney injury, and 297 (15%) with severe acute kidney injury. The impact of acute kidney injury on the ventilatory management of patients with acute respiratory distress syndrome was relatively limited, with no differences in arterial CO2 tension or in tidal or minute ventilation between the groups. Hospital mortality increased from 31% in acute respiratory distress syndrome patients with no acute kidney injury to 50% in mild-moderate acute kidney injury (p |
| Databáze: | OpenAIRE |
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