Cognition in multiple system atrophy: a single‐center cohort study

Autor:	Elfriede Karner, Gregor K. Wenning, Klaus Seppi, Christoph Rabensteiner, Beatrice Heim, Christine Kaindlstorfer, Thomas Bodner, Katherina J. Mair, Florian Krismer, Cecilia Raccagni, Alessandra Fanciulli, Sabine Eschlböck, Antonio Heras Garvin, Werner Poewe, Margarete Delazer
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	0301 basic medicine Male medicine.medical_specialty Neurology Neurosciences. Biological psychiatry. Neuropsychiatry Audiology Anxiety Neuropsychological Tests Hospital Anxiety and Depression Scale 03 medical and health sciences Executive Function Hypotension Orthostatic 0302 clinical medicine mental disorders Memory span medicine Verbal fluency test Humans Cognitive Dysfunction RC346-429 Research Articles Aged Retrospective Studies business.industry Depression General Neuroscience Cognition Middle Aged Multiple System Atrophy Executive functions 030104 developmental biology Female Neurology (clinical) Neurology. Diseases of the nervous system medicine.symptom Verbal memory business 030217 neurology & neurosurgery Research Article RC321-571
Zdroj:	Annals of Clinical and Translational Neurology, Vol 7, Iss 2, Pp 219-228 (2020) Annals of Clinical and Translational Neurology
ISSN:	2328-9503
Popis:	Objective Cognitive impairment in multiple system atrophy (MSA) is common, but remain poorly characterized. We evaluated cognitive and behavioral features in MSA patients and assessed between‐group differences for MSA subtypes and the effect of orthostatic hypotension (OH) on cognition. Methods This retrospective study included 54 patients with clinical diagnosis of possible and probable MSA referred to the Department of Neurology at Medical University of Innsbruck between 2000 and 2018. Neurological work‐up included comprehensive neuropsychological testing including Consortium to Establish a Registry for Alzheimer's Disease (CERAD‐plus) test battery, Frontal Assessment Battery (FAB), digit span test (DST), clock drawing task (CLOX1), and Hospital Anxiety and Depression Scale (HADS‐D). Results The mean MMSE score was 27.6 points. Overall, slight to moderate cognitive impairment was noted in up to 40% of patients, with predominant impairment of executive function and verbal memory. Patients with the cerebellar variant performed significantly worse than patients with the parkinsonian type (P
Databáze:	OpenAIRE
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