Squared-Off Nuclei and 'Appliqué' Pattern as a Histopathological Clue to Periocular Sebaceous Carcinoma: A Clinicopathological Study of 50 Neoplasms From 46 Patients
| Autor: | Liubov Kyrpychova, Dmitry V. Kazakov, Denisa Kacerovska, Sigrid M. C. Broekaert, Katrin Kerl, Natalja Denisjuk, Michal Michal, Doina Ivan, Philipp Ströbel, Katharina Flux, Michael P. Schön |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Sebaceous Gland Neoplasm Dermatology Eye neoplasm Pathology and Forensic Medicine 030207 dermatology & venereal diseases 03 medical and health sciences Young Adult 0302 clinical medicine Sebaceous Differentiation medicine Neoplasm Humans Sebaceous Gland Neoplasms Aged Aged 80 and over business.industry Poorly differentiated Eye Neoplasms Adenocarcinoma Sebaceous General Medicine Middle Aged medicine.disease medicine.anatomical_structure 030221 ophthalmology & optometry Adenocarcinoma Female Eyelid business Sebaceous carcinoma |
| Zdroj: | The American Journal of dermatopathology. 39(4) |
| ISSN: | 1533-0311 |
| Popis: | The histopathological diagnosis of periocular sebaceous carcinoma can be difficult in poorly differentiated cases showing few mature sebocytes. The authors examined 50 periocular sebaceous carcinomas from 46 patients to determine the frequency of 2 features seen in this neoplasm, namely cells with squared-off nuclei and so-called "applique" pattern (peritumoral subnecrosis of peripherally located neoplastic cells). Neoplastic cells with squared-off nuclei were found in varying numbers in both the intraepithelial and dermal (invasive) components in all neoplasms, whereas the applique pattern was observed in a third of the cases. It is concluded that these features, taken together, may serve as a clue for the diagnosis of periocular sebaceous carcinoma. |
| Databáze: | OpenAIRE |
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