High-energy collision-induced dissociation of radiosensitizer anions: Nimorazole and metronidazole
| Autor: | Stephan Denifl, Linda Feketeová, Jusuf M. Khreis, S Pandeti |
|---|---|
| Přispěvatelé: | Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3) |
| Rok vydání: | 2018 |
| Předmět: |
[PHYS]Physics [physics]
Nimorazole Collision-induced dissociation Electrospray ionization 010401 analytical chemistry 010402 general chemistry Condensed Matter Physics Photochemistry Mass spectrometry 01 natural sciences Dissociation (chemistry) 0104 chemical sciences Ion chemistry.chemical_compound Deprotonation chemistry medicine Imidazole Physical and Theoretical Chemistry Instrumentation Spectroscopy medicine.drug |
| Zdroj: | Int.J.Mass Spectrometry Int.J.Mass Spectrometry, 2018, 431, pp.1-7. ⟨10.1016/j.ijms.2018.05.015⟩ |
| ISSN: | 1387-3806 |
| DOI: | 10.1016/j.ijms.2018.05.015 |
| Popis: | International audience; The formation of radical anions of nitroimidazolic radiosensitizers, nimorazole and metronidazole, and their unimolecular dissociation reactions upon high-energy collisions with He gas were investigated with a double focusing mass spectrometer equipped with an electrospray ionization (ESI) source. Radical anions of both, nimorazole and metronidazole, are readily formed in the ESI process, while for the metronidazole also the deprotonated anion is formed. A variety of dissociation channels is observed and the associated kinetic energy released in the dissociation for most of these channels is reported. The marker anion NO2 − is observed in the dissociation of all studied anions. The release of NO• radical from the radical anions is associated with surprisingly small kinetic energy release in comparison to simple nitroimidazoles. On the other hand, the highest kinetic energy release is noted for the release of the neutral side group from N1 position of the imidazole ring, which suggests that the substitution at the N1 plays a crucial role in the decomposition of anions of radiosensitizers |
| Databáze: | OpenAIRE |
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