Long-Term Follow-Up of Sepsis Induced Immunoparalysis

Autor:	E. R. Longbottom, Michael J. O’Dwyer, Charles J. Hinds, Rupert M Pearse, P. Zolfaghari, Hdt Torrance, Mark Vivian, M. Raja, AJ Stroud
Rok vydání:	2015
Předmět:	Sepsis medicine.medical_specialty Recurrent infections business.industry Long term follow up medicine Oral Presentation Critical Care and Intensive Care Medicine Intensive care medicine medicine.disease business Severe sepsis
Zdroj:	Intensive Care Medicine Experimental
ISSN:	2197-425X
DOI:	10.1186/2197-425x-3-s1-a49
Popis:	Severe sepsis induces a state of immunoparalysis.[1] Animal models have demonstrated this to be secondary to microbial-induced host epigenetic alterations, which persist and are associated with long-term immunoparalysis.[2] Whilst human sepsis is associated with poor long-term outcomes in conjunction with recurrent infections,[3] it is not clear if the immunoparalysed state persists following recovery from the initial septic insult.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4959ffa2af424db596cf8037ee6d60d https://doi.org/10.1186/2197-425x-3-s1-a49 Zobrazit plný text záznamu Full text from SpringerLink