Conjunctival Biopsy in Scleroderma and Primary Sjögren's Syndrome
| Autor: | Bernard Gosselin, Pierre Y. Hatron, Anne Janin, Erica Mancel, Didier Gosset |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
Male Systemic disease Pathology medicine.medical_specialty Biopsy Eye disease Keratoconjunctivitis Sicca Conjunctival biopsy Lymphocytic Infiltrate stomatognathic system Fibrosis medicine Humans KERATOCONJUNCTIVITIS SICCA skin and connective tissue diseases Aged Aged 80 and over Scleroderma Systemic integumentary system business.industry Middle Aged medicine.disease Connective tissue disease eye diseases stomatognathic diseases Ophthalmology Sjogren's Syndrome Microscopy Electron Scanning Female business Complication Conjunctiva |
| Zdroj: | American Journal of Ophthalmology. 115:792-799 |
| ISSN: | 0002-9394 |
| DOI: | 10.1016/s0002-9394(14)73650-5 |
| Popis: | Keratoconjunctivitis sicca complicates both scleroderma and Sjögren's syndrome. Scleroderma of recent onset is difficult to diagnose, but is easily recognized late in its course. To assess the value of the conjunctival biopsy in the diagnosis of scleroderma, we used light, scanning, and transmission electron microscopy to compare in a masked fashion specimens from 21 patients with scleroderma and 14 patients with primary Sjögren's syndrome. Epithelial changes permitted diagnosis of early scleroderma in the two groups of patients. Lymphocytic infiltrate was always present in Sjögren's syndrome, but not in scleroderma. Fibrosis was always found in scleroderma, even in scleroderma of recent onset, but was absent in Sjögren's syndrome. The fibrosis was distributed around capillaries in a band-like pattern and was associated with degranulating mast cells. Conjunctival biopsy is valuable for the early diagnosis of scleroderma and for differentiating between scleroderma and primary Sjögren's syndrome. |
| Databáze: | OpenAIRE |
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