Impaired left atrial reservoir and conduit strain in patients with atrial fibrillation and extensive left atrial fibrosis
| Autor: | Anja M. van der Laan, Cornelis P Allaart, Ahmet Demirkiran, Marco J.W. Götte, Albert C. van Rossum, Luuk H. G. A. Hopman, Pranav Bhagirath, Mark J. Mulder |
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| Přispěvatelé: | Cardiology, ACS - Heart failure & arrhythmias, ACS - Microcirculation |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Contrast Media Gadolinium Strain (injury) Predictive Value of Tests Left atrial Fibrosis Atrial strain Internal medicine medicine Humans Diseases of the circulatory (Cardiovascular) system Radiology Nuclear Medicine and imaging Sinus rhythm cardiovascular diseases Angiology Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Research Atrial fibrillation Magnetic resonance imaging Atrial fibrosis medicine.disease RC666-701 Cardiology cardiovascular system Atrial remodeling Cardiology and Cardiovascular Medicine business Cardiovascular magnetic resonance (CMR) |
| Zdroj: | Hopman, L H G A, Mulder, M J, van der Laan, A M, Demirkiran, A, Bhagirath, P, van Rossum, A C, Allaart, C P & Götte, M J W 2021, ' Impaired left atrial reservoir and conduit strain in patients with atrial fibrillation and extensive left atrial fibrosis ', Journal of Cardiovascular Magnetic Resonance, vol. 23, no. 1, 131 . https://doi.org/10.1186/s12968-021-00820-6 Journal of Cardiovascular Magnetic Resonance, 23(1):131. BioMed Central Journal of Cardiovascular Magnetic Resonance, Vol 23, Iss 1, Pp 1-10 (2021) Journal of Cardiovascular Magnetic Resonance |
| ISSN: | 1097-6647 |
| DOI: | 10.1186/s12968-021-00820-6 |
| Popis: | Background Atrial fibrillation (AF) is associated with profound structural and functional changes in the atria. In the present study, we investigated the association between left atrial (LA) phasic function and the extent of LA fibrosis using advanced cardiovascular magnetic resonance (CMR) imaging techniques, including 3-dimensional (3D) late gadolinium enhancement (LGE) and feature tracking. Methods Patients with paroxysmal and persistent AF (n = 105) underwent CMR in sinus rhythm. LA global reservoir strain, conduit strain and contractile strain were derived from cine CMR images using CMR feature tracking. The extent of LA fibrosis was assessed from 3D LGE images. Healthy subjects underwent CMR and served as controls (n = 19). Results Significantly lower LA reservoir strain, conduit strain and contractile strain were found in AF patients, as compared to healthy controls (− 15.9 ± 3.8% vs. − 21.1 ± 3.6% P P P = 0.02, respectively). Patients with a high degree of LA fibrosis (dichotomized by the median value) had lower reservoir strain and conduit strain compared to patients with a low degree of LA fibrosis (− 15.0 ± 3.9% vs. − 16.9 ± 3.3%, P = 0.02 and − 7.9 ± 2.7% vs. − 9.5 ± 2.6%, P = 0.01, respectively). In contrast, no difference was found for LA contractile strain (− 7.1 ± 2.4% vs. − 7.4 ± 2.3%, P = 0.55). Conclusions Impaired LA reservoir and conduit strain are present in AF patients with extensive atrial fibrosis. Future studies are needed to examine the biologic nature of this association and possible therapeutic implications. |
| Databáze: | OpenAIRE |
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