Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome
| Autor: | Benjamin H. Eidelman, Alana Stephens, Rocco J. Cannistraro, D. Jane Hata, Tara L. Becker, Pramod Guru, Lisa Brumble |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
lcsh:R5-920 Gastrointestinal tract Pathology medicine.medical_specialty Flaccid paralysis biology business.industry Disease Gut flora Short bowel syndrome medicine.disease biology.organism_classification Pathophysiology Pathogenesis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine Botulism medicine.symptom lcsh:Medicine (General) business 030217 neurology & neurosurgery |
| Zdroj: | Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 2, Iss 3, Pp 291-296 (2018) |
| ISSN: | 2542-4548 |
| DOI: | 10.1016/j.mayocpiqo.2018.06.005 |
| Popis: | The cholinergic heat-labile neurotoxin produced by Clostridium species is primarily responsible for the clinical manifestations of botulism. The classic phenotypic presentation of botulism consists of subacute descending flaccid paralysis with intact sensory function. Traditionally, it is classified into 3 main forms (foodborne, wound-related, and infantile) on the basis of primary site of toxin entry into the human nervous system. Toxemia is the common pathophysiology in all forms of botulism. Adult intestinal toxemia botulism is an extremely rare form of the disease with pathogenesis similar to that of infant-type botulism. Symptomatic adults usually have an anatomic abnormality in the gastrointestinal tract leading to changes in normal gut flora. The current case is an addition to the growing literature on this unusual clinical variant of botulism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|