Stress-induced desensitization of alpha 2-adrenergic receptors in human platelets
| Autor: | D Keegan, P Migály, J. I. Javaid, J Embury, Robert Freedman, John M. Davis, G. N. Pandey |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Blood Platelets Male medicine.medical_specialty Adrenergic receptor medicine.medical_treatment Iodocyanopindolol Radioligand Assay Internal medicine Receptors Adrenergic beta medicine Leukocytes Humans Platelet Protease-activated receptor Applied Psychology Desensitization (medicine) Chemistry Stress induced Yohimbine Receptors Adrenergic alpha Psychiatry and Mental health Endocrinology Pindolol Anxiety Alpha-2 adrenergic receptor Female medicine.symptom Arousal Stress Psychological medicine.drug |
| Zdroj: | Psychosomatic medicine. 52(6) |
| ISSN: | 0033-3174 |
| Popis: | Although agonist-induced desensitization of adrenergic receptors has been previously demonstrated, the regulation of adrenergic receptors during acute psychological stress has not been investigated in humans. We studied 30 first year medical students during final examination week and one month earlier. Platelet alpha 2 receptor binding was measured using 3H-yohimbine and leukocyte beta 2 receptor binding was measured with 125I-CYP (Iodocyanopindolol). During final examination week, platelet alpha 2-receptor binding affinity was significantly reduced, while levels of plasma catecholamines and reported anxiety were significantly increased, compared with the earlier period. Students showing the greatest increases in plasma norepinephrine and in reported anxiety also demonstrated the greatest reductions in alpha 2 receptor binding affinity. These data show that acute psychological stress can produce adrenergic receptor desensitization, possibly through increased levels of circulating norepinephrine. |
| Databáze: | OpenAIRE |
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