Cardiac Micro–Computed Tomography Imaging of the Aging Coronary Vasculature
| Autor: | Gerald E. Harders, Fernando L. Martin, Tomoko Ichiki, John C. Burnett, Paul M. McKie, Diego Bellavia, S. Jeson Sangaralingham, Amir Lerman, Christopher G. Scott, Erik L. Ritman |
|---|---|
| Přispěvatelé: | Sangaralingham, SJ, Ritman, EL, McKie, PM, Ichiki, T, Lerman, A, Scott, CG, Martin, FL, Harders, GE, Bellavia, D, Burnett, JC Jr. |
| Rok vydání: | 2012 |
| Předmět: |
Aging
medicine.medical_specialty X-ray microtomography Blood Pressure Article Ventricular Dysfunction Left Coronary circulation Imaging Three-Dimensional Fibrosis Coronary Circulation Internal medicine Lv dysfunction Animals Medicine Radiology Nuclear Medicine and imaging business.industry Micro computed tomography Coronary vasculature Imaging study X-Ray Microtomography medicine.disease Settore MED/11 - Malattie Dell'Apparato Cardiovascolare Rats Inbred F344 Rats medicine.anatomical_structure Blood pressure Echocardiography High resolution imaging techinques Linear Models Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Circulation: Cardiovascular Imaging. 5:518-524 |
| ISSN: | 1942-0080 1941-9651 |
| DOI: | 10.1161/circimaging.112.973057 |
| Popis: | Background— Alterations at the level of the coronary circulation with aging may play an important role in the evolution of age-associated changes in left ventricular (LV) fibrosis and function. However these age-associated changes in the coronary vasculature remain poorly defined primarily due to the lack of high resolution imaging technologies. The current study was designed to utilize cardiac micro–computed tomography (micro-CT) technology as a novel imaging strategy, to define the 3-dimensional coronary circulation in the young and aged heart and its relationship to LV fibrosis and function. Methods and Results— Young (2 months old; n=10) and aged (20 months old; n=10) Fischer rats underwent cardiac micro-CT imaging as well as echocardiography, blood pressure, and fibrosis analysis. Importantly, when indexed to LV mass, which increased with age, the total and intramyocardial vessel volumes were lower, whereas the epicardial vessel volume, with and without indexing to LV mass, was significantly higher in the aged hearts compared with the young hearts. Moreover, the aged hearts had a significantly lower percentage of intramyocardial vessel volume and a significantly higher percentage of epicardial vessel volume, when normalized to the total vessel volume, compared with the young hearts. Further, the aged hearts had significant LV fibrosis and mild LV dysfunction compared with the young hearts. Conclusions— This micro-CT imaging study reports the reduction in normalized intramyocardial vessel volume within the aged heart, in association with increased epicardial vessel volume, in the setting of increased LV fibrosis, and mild LV dysfunction. |
| Databáze: | OpenAIRE |
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