Inflammation, angiogenesis and coagulation interplay in a variety of retinal diseases
| Autor: | Yael Nisgav, Alon Zahavi, Tami Livnat, Idit Dan‐Brezis, Rita Ehrlich, Dov Weinberger, Mor Dahbash, Ruth Axer-Siegel |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Angiogenesis medicine.medical_treatment Retinal detachment Vitrectomy General Medicine Diabetic retinopathy medicine.disease eye diseases Vascular endothelial growth factor 03 medical and health sciences Ophthalmology Tissue factor chemistry.chemical_compound 0302 clinical medicine Tissue factor pathway inhibitor chemistry 030221 ophthalmology & optometry medicine sense organs Epiretinal membrane business 030217 neurology & neurosurgery |
| Zdroj: | Acta Ophthalmologica. 98 |
| ISSN: | 1755-3768 1755-375X |
| Popis: | PURPOSE To evaluate and correlate levels of various proteins involved in coagulation, inflammation and angiogenesis processes in the vitreous of patients with different vitreoretinal pathologies. METHODS Vitreous samples were collected from patients scheduled for pars plana vitrectomy for the treatment of rhegmatogenous retinal detachment (RRD), vitreous haemorrhage or tractional retinal detachment associated with proliferative diabetic retinopathy (PDR). Macular hole and epiretinal membrane served as controls. Levels of vascular endothelial growth factor, thrombin-antithrombin III complex, interleukin-8, tissue factor, thrombomodulin, P-selectin, D-dimer and tissue factor pathway inhibitor were compared among the vitreoretinal pathology groups. RESULTS Compared to controls, patients with PDR had significantly higher levels of thrombin-antithrombin III complex (p |
| Databáze: | OpenAIRE |
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