Stability studies on piriprost and piriprost potassium using high-performance liquid chromatography
| Autor: | S.M. Plaisted, Don L. Theis, B.G. Snider |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Leukotriene synthesis
chemistry.chemical_classification Chromatography Light Chemistry Metal ions in aqueous solution Potassium Organic Chemistry chemistry.chemical_element Salt (chemistry) Humidity General Medicine Hydrogen-Ion Concentration Epoprostenol Biochemistry High-performance liquid chromatography Analytical Chemistry Kinetics Drug Stability Metals Bulk samples Piriprost Potassium Oxidation-Reduction Chromatography High Pressure Liquid |
| Zdroj: | Journal of Chromatography A. 367:254-259 |
| ISSN: | 0021-9673 |
| DOI: | 10.1016/s0021-9673(00)94842-8 |
| Popis: | Piriprost potassium [potassium salt of 6,9-deepoxy-6,9(phenylimino)-d 6*8prostaglandin I1 (Fig. 1) is a selective inhibitor of leukotriene synthesis and is currently the subject of clinical studieslp4. An analytical method was needed to analyze bulk samples of piriprost and potassium piriprost. Our efforts to develop such a method showed rapid degradation of piriprost in solution. Extensive stability studies were necessary to identify conditions where piriprost was stable during the analysis. The effects of pH, light, degree of aeration and presence of metal ions were investigated. Conditions were identified where samples could be analyzed within a 3-h time period. |
| Databáze: | OpenAIRE |
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