The Neurodevelopmental Basis of Early Childhood Disruptive Behavior: Irritable and Callous Phenotypes as Exemplars
| Autor: | Lauren S. Wakschlag, Daniel S. Pine, Margaret J. Briggs-Gowan, Susan B. Perlman, R. James R. Blair, Ellen Leibenluft |
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| Rok vydání: | 2018 |
| Předmět: |
Regulation of emotion
05 social sciences Poison control Context (language use) Irritability Child development Article Phobic disorder Developmental psychology 03 medical and health sciences Psychiatry and Mental health 0302 clinical medicine medicine 0501 psychology and cognitive sciences Early childhood Irritable Mood medicine.symptom Psychology 030217 neurology & neurosurgery 050104 developmental & child psychology Clinical psychology |
| Zdroj: | American Journal of Psychiatry. 175:114-130 |
| ISSN: | 1535-7228 0002-953X |
| Popis: | The Journal’s 175th anniversary combined with recent advances in research provides an ideal opportunity to present a neurodevelopmental roadmap for understanding, preventing, and treating psychiatric disorders. Such a roadmap is particularly relevant for early childhood onset neurodevelopmental conditions, which emerge when experience-dependent neuroplasticity is at its peak. Employing a novel developmental specification approach, this review places recent neurodevelopmental research on early childhood disruptive behavior within the historical context of The Journal. We highlight irritability and callous behavior as two core exemplars of early disruptive behavior. Both phenotypes can be reliably differentiated from normative variation as early as the first years of life. Both link to discrete pathophysiology: irritability with disruptions in prefrontal regulation of emotion, and callous behavior with abnormal fear processing. Each phenotype also possesses clinical and predictive utility. Based on a nomologic net of evidence, we conclude that early disruptive behavior is neurodevelopmental in nature, and should be reclassified as an early childhood-onset neurodevelopmental condition in DSM 5. Rapid translation from neurodevelopmental discovery to clinical application has transformative potential for psychiatric approaches of the millennium. |
| Databáze: | OpenAIRE |
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