Analysis of Second-order Kernel Response Components of Multifocal Electroretinograms Elicited from Normal Subjects
| Autor: | Hiroshi Wada, Toshio Enoki, Masaru Yoshii, Fumito Sakemi, Kenji Yanashima, Shigekuni Okisaka |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Retinal Ganglion Cells Retina genetic structures medicine.diagnostic_test Significant difference Healthy subjects food and beverages Retinal General Medicine Anatomy Stimulus (physiology) Retinal ganglion Ophthalmology chemistry.chemical_compound medicine.anatomical_structure Kernel (image processing) chemistry Electroretinography medicine Humans Mathematics Biomedical engineering |
| Zdroj: | Japanese Journal of Ophthalmology. 45:247-251 |
| ISSN: | 0021-5155 |
| DOI: | 10.1016/s0021-5155(00)00384-1 |
| Popis: | Purpose: It has been reported that the second-order kernel response components of multifocal electroretinograms (mERGs) reflect the electrical activity of the inner retinal layers. In this study, we have investigated whether the amplitudes of the second-order kernel response components correlate with the spatial distribution of human retinal ganglion cells. Methods: Multifocal electroretinograms were recorded using the Veris III™ system from 5 healthy subjects with different stimulus and recording parameters. The mERGs were analyzed using the Veris Science™ software programs. The stimuli consisted of densely arranged arrays of 103, 61, 37 or 19 hexagonal elements. Four minutes were required to record one set of mERG responses using 8 sessions, and 8 minutes using 16 sessions. The second-order kernel response components were extracted and analyzed using the Veris Science™ program. Results: The signal-to-noise ratio of the first-order kernel response components was improved considerably by the summation of the nine reproducible responses from the same subject but the second-order kernel response components were not. The summation of the nine reproducible responses was insufficient to identify an array of the second-order kernel response components. Both the first- and second-order kernel response components were larger when fewer hexagonal elements were used. There was no significant difference in the individual responses between the 4-minute and the 8-minute recordings. A response density analysis revealed a weak correlation between the amplitude distribution of the second-order kernel response components and the spatial distribution of human retinal ganglion cells. Conclusions: The distribution of the amplitudes of the second-order kernel response components of the mERGs elicited from normal subjects did not correlate with the distribution of human ganglion cells. This suggests that the theory that second-order kernel response components arise from the activity of retinal ganglion cells should be reconsidered. |
| Databáze: | OpenAIRE |
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