Cooperative antithrombotic effect from the simultaneous inhibition of thrombin and factor Xa
| Autor: | Patricia Andrade-Gordon, Barbara J. Haertlein, Bruce P. Damiano, Bruce E. Maryanoff, Michael J. Costanzo, Edward C. Giardino, Lawrence de Garavilla |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.drug_mechanism_of_action Factor Xa Inhibitor Naphthalenes Pharmacology Arginine Guanidines Argatroban Rats Sprague-Dawley Thrombin Piperidines In vivo Antithrombotic medicine Animals Humans Blood Coagulation Sulfonamides Chemistry Antithrombin Drug Synergism Hematology General Medicine Heparin Rats Biochemistry Pipecolic Acids Factor Xa Factor Xa Inhibitors medicine.drug Discovery and development of direct thrombin inhibitors |
| Zdroj: | Blood Coagulation & Fibrinolysis. 21:128-134 |
| ISSN: | 0957-5235 |
| Popis: | Whereas heparin functions as an antithrombotic agent by promoting antithrombin III-based inhibition of thrombin and factor Xa, there is less appreciation for the combination behavior with small-molecule, direct inhibitors of these proteases. We conducted a study in a high-shear arterial environment to explore the potential for a cooperative antithrombotic effect with a thrombin inhibitor (argatroban), a factor Xa inhibitor (YM-60828), and a dual thrombin/factor Xa inhibitor (RWJ-445167). We employed a platelet-dependent vascular injury model in which rats were subjected to an acute electrical injury to the carotid artery. Antithrombotic efficacy was measured for thrombin inhibitor argatroban and factor Xa inhibitor YM-60828 administered alone or in combination. The results indicate that there is a cooperative antithrombotic effect in vivo when both thrombin and factor Xa are inhibited simultaneously. The dual thrombin/factor Xa inhibitor RWJ-445167 was found to have potent antithrombotic activity in this high-shear environment. A comparison of results for RWJ-445167 and argatroban showed additional efficacy with RWJ-445167, suggestive of drug synergy. |
| Databáze: | OpenAIRE |
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