High Mobility Group A proteins in esophageal carcinomas
| Autor: | Luis Felipe Ribeiro Pinto, Nathalia Meireles Da Costa, Francesco Esposito, Antonio Palumbo Junior, Alfredo Fusco |
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| Přispěvatelé: | Palumbo Júnior, Antonio, Da Costa, Nathalia Meirele, Esposito, Francesco, Fusco, Alfredo, Pinto, Luis Felipe Ribeiro |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
HMGA protein
0301 basic medicine Esophageal Neoplasms Carcinogenesis Adenocarcinoma Models Biological Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine HMGA2 medicine Humans HMGA based therapy esophageal cancer malignant phenotype HMGA Proteins Molecular Biology biology diagnostic marker Medicine (all) Extra View HMGA proteins HMGA Cancer Cell Biology Esophageal cancer medicine.disease HMGA1 030104 developmental biology High-mobility group Cell culture 030220 oncology & carcinogenesis Immunology biology.protein Cancer research Developmental Biology |
| Zdroj: | Cell cycle (Georgetown, Tex. Online) 15 (2016): 2410–2413. doi:10.1080/15384101.2016.1215388 info:cnr-pdr/source/autori:Palumbo Junior A.; Da Costa N.M.; Esposito F.; Fusco A.; Pinto L.F.R./titolo:High Mobility Group A proteins in esophageal carcinomas/doi:10.1080%2F15384101.2016.1215388/rivista:Cell cycle (Georgetown, Tex. Online)/anno:2016/pagina_da:2410/pagina_a:2413/intervallo_pagine:2410–2413/volume:15 |
| DOI: | 10.1080/15384101.2016.1215388 |
| Popis: | We have recently shown that HMGA2 is overexpressed in esophageal squamous cell carcinoma (ESCC) and its detection allows to discriminate between cancer and normal surrounding tissue proposing HMGA2 as a novel diagnostic marker. Interestingly, esophageal adenocarcinoma shows an opposite behavior with the overexpression of HMGA1 but not HMGA2. Moreover, we show that the suppression of HMGA2 in 2 ESCC cell lines reduces the malignant phenotype. Then, this paper highlights a differential induction of the HMGA proteins, depending on the cancer histological type, and reinforces the perspective of an innovative esophageal cancer therapy based on the suppression of the HMGA protein function and/or expression. |
| Databáze: | OpenAIRE |
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