Combinatorial Approach Using Caenorhabditis elegans and Mammalian Systems for Aging Research
Autor: | Seung-Jae Lee, Jooyeon Sohn, Gee-Yoon Lee |
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Rok vydání: | 2021 |
Předmět: |
combinatorial approach
ved/biology.organism_classification_rank.species mammal Computational biology Mice Animals Humans Caenorhabditis elegans Model organism Molecular Biology Mechanistic target of rapamycin PI3K/AKT/mTOR pathway Mammals biology ved/biology aging Autophagy Translation (biology) Cell Biology General Medicine Geroscience biology.organism_classification Disease Models Animal Sirtuin biology.protein Minireview Signal transduction lifespan |
Zdroj: | Molecules and Cells |
ISSN: | 0219-1032 |
Popis: | Aging is associated with functional and structural declines in organisms over time. Organisms as diverse as the nematode Caenorhabditis elegans and mammals share signaling pathways that regulate aging and lifespan. In this review, we discuss recent combinatorial approach to aging research employing C. elegans and mammalian systems that have contributed to our understanding of evolutionarily conserved aging-regulating pathways. The topics covered here include insulin/IGF-1, mechanistic target of rapamycin (mTOR), and sirtuin signaling pathways; dietary restriction; autophagy; mitochondria; and the nervous system. A combinatorial approach employing high-throughput, rapid C. elegans systems, and human model mammalian systems is likely to continue providing mechanistic insights into aging biology and will help develop therapeutics against age-associated disorders. |
Databáze: | OpenAIRE |
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