Exogenous neuropeptide Y blocks myoelectric activity in the upper gastrointestinal tract of starved dogs. Brain neuropeptide Y converts a fasting pattern of myoelectric activity to a fed pattern
| Autor: | Theodore N. Pappas, K. Chung, William C. Meyers, H. J. Thomson, L. A. Saperstein, Marwan Farouk, Justin Geoghegan |
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| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.medical_treatment Central nervous system Bolus (medicine) Dogs Internal medicine mental disorders medicine Carnivora Upper gastrointestinal Animals Neuropeptide Y Saline Migrating motor complex Injections Intraventricular Myoelectric Complex Migrating biology digestive oral and skin physiology Fissipedia Gastroenterology Brain Fasting biology.organism_classification Neuropeptide Y receptor humanities Endocrinology medicine.anatomical_structure Food Female Gastrointestinal Motility |
| Zdroj: | Scandinavian journal of gastroenterology. 28(6) |
| ISSN: | 0036-5521 |
| Popis: | The effect of intracerebroventricular (ICV) neuropeptide Y (NPY) on the migrating motor complex (MMC) was examined in five starved dogs. Myoelectric activity was recorded using gastric, duodenal, and jejunal electrodes. Intragastric pressure was monitored via a gastric fistula, and ICV injections were given through a cerebroventricular guide. Recordings were made with no ICV injection and before and after 250-microliters bolus injections of vehicle as control (0.1% dog serum albumin in saline) or 500 pmol/kg NPY. The mean interval between MMCs was 98 +/- 10 min without ICV injection and 96 +/- 7 min after control solution. After ICV injection of NPY no further MMCs were recorded in any dog, even though the study was continued for a minimum of 3.5 h. Instead, the myoelectric pattern became indistinguishable from that in fed dogs. We conclude that central NPY plays a role in modulation of upper gastrointestinal myoelectric activity. This may reflect a central regulatory role for NPY in the coordination of feeding. |
| Databáze: | OpenAIRE |
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