Drug delivery system on the base of phospholipid nanoparticles for rifampicin
| Autor: | M A Sanzhakov, O. M. Ipatova, E G Tikhonova, V N Prozorovskiĭ, N V Medvedeva, T I Tarkhovskaia |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Drug medicine.drug_class media_common.quotation_subject Antibiotics Phospholipid Pharmacology General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound Drug Delivery Systems Oral administration Phosphatidylcholine polycyclic compounds medicine Animals Particle Size Rats Wistar Antibiotics Antitubercular Phospholipids media_common General Medicine bacterial infections and mycoses Rats Bioavailability chemistry Drug delivery Nanoparticles Rifampin Rifampicin Oleic Acid medicine.drug |
| Zdroj: | Biomeditsinskaya Khimiya. 59:585-590 |
| ISSN: | 2310-6905 2310-6972 |
| Popis: | Low bioavailability of rifampicin, one of the main antituberculous drug, stimulates searches of its new optimized formulations. The present study has showen possibility of rifampicin embedding into nanoparticles from plant phosphatidylcholine (diameter of 20-30 nm). Addition of sodium oleate to the phospholipid system caused a 2-fold increase of the percent of rifampicin incorporation. After oral administration to rats, the maximal drug observed in plasma one hour after was 0.5 and 4.2 mkg/ml for free rifampicin for rifampicin in phospholipids-oleate nanoparticles, respectively. These levels were maintained for more than two hours of the experiment. High rifampicin bioavailability in the oleate containing phospholipid nanosystem suggests prospectivity of its pharmaceutical elaboration. |
| Databáze: | OpenAIRE |
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