Behavior‐dependent activity patterns of GABAergic long‐range projecting neurons in the rat hippocampus
| Autor: | Daniel A. Swiejkowski, Ornella Valenti, Zsolt Borhegyi, Thomas Klausberger, Ben Micklem, Peter Somogyi, Tim J. Viney, Linda Katona, Dimitrios Kotzadimitriou |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Cognitive Neuroscience Action Potentials Biotin Hippocampus somatostatin Motor Activity Hippocampal formation Biology CA1 Rats Sprague-Dawley 03 medical and health sciences Glutamatergic 0302 clinical medicine sharp wave‐ripples Animals Premovement neuronal activity Single-unit recording GABAergic Neurons Theta Rhythm Wakefulness theta oscillations Research Articles Signal Processing Computer-Assisted Electrodes Implanted dendritic inhibition 030104 developmental biology Somatostatin nervous system GABAergic Sleep Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | Hippocampus |
| ISSN: | 1098-1063 1050-9631 |
| DOI: | 10.1002/hipo.22696 |
| Popis: | Long‐range glutamatergic and GABAergic projections participate in temporal coordination of neuronal activity in distributed cortical areas. In the hippocampus, GABAergic neurons project to the medial septum and retrohippocampal areas. Many GABAergic projection cells express somatostatin (SOM+) and, together with locally terminating SOM+ bistratified and O‐LM cells, contribute to dendritic inhibition of pyramidal cells. We tested the hypothesis that diversity in SOM+ cells reflects temporal specialization during behavior using extracellular single cell recording and juxtacellular neurobiotin‐labeling in freely moving rats. We have demonstrated that rare GABAergic projection neurons discharge rhythmically and are remarkably diverse. During sharp wave‐ripples, most projection cells, including a novel SOM+ GABAergic back‐projecting cell, increased their activity similar to bistratified cells, but unlike O‐LM cells. During movement, most projection cells discharged along the descending slope of theta cycles, but some fired at the trough jointly with bistratified and O‐LM cells. The specialization of hippocampal SOM+ projection neurons complements the action of local interneurons in differentially phasing inputs from the CA3 area to CA1 pyramidal cell dendrites during sleep and wakefulness. Our observations suggest that GABAergic projection cells mediate the behavior‐ and network state‐dependent binding of neuronal assemblies amongst functionally‐related brain regions by transmitting local rhythmic entrainment of neurons in CA1 to neuronal populations in other areas. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text