Diuretic induced hypokalaemia: relationship to dosage interval and plasma aldosterone
| Autor: | JR Shelton, IR Harrison, GT McInnes, G. V. Rigby, RM Perkins |
|---|---|
| Rok vydání: | 1982 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Hypokalemia Pharmacology Drug Administration Schedule chemistry.chemical_compound Hydrochlorothiazide Internal medicine medicine Humans Pharmacology (medical) Diuretics Aldosterone Healthy subjects Middle Aged Crossover study Endocrinology chemistry Serum potassium Potassium Spironolactone Once daily Diuretic Research Article medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 14:449-452 |
| ISSN: | 0306-5251 |
| DOI: | 10.1111/j.1365-2125.1982.tb02007.x |
| Popis: | Plasma potassium and aldosterone responses to 9 days treatment with hydrochlorothiazide (100 mg/day) alone or in combination with spironolactone (100 mg/day), prescribed once daily or in doses 12 h apart, were examined in a double-blind, crossover study in twelve healthy subjects. Plasma potassium concentrations were lower when the drugs were administered 12 h apart (P less than 0.01). Spironolactone attenuated significantly hydrochlorothiazide induced hypokalaemia--mean rise in plasma potassium, 0.36 mmol/l (P less than 0.001). The increase in plasma aldosterone was greater following combination therapies (P less than 0.001), but there were no significant differences between once daily and twice daily regimens. We conclude that plasma potassium concentration is better maintained when diuretics are given once daily and that this is not related closely to differences in plasma aldosterone responses. |
| Databáze: | OpenAIRE |
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