The Association of Combined Total Kidney and Liver Volume with Pain and Gastrointestinal Symptoms in Patients with Later Stage Autosomal Dominant Polycystic Kidney Disease
| Autor: | Joost P.H. Drenth, Annemarie L. Messchendorp, Niek F. Casteleijn, Darius Soonawala, Ron T. Gansevoort, Maartje D A van Gastel, Tom J. G. Gevers, Dorien J.M. Peters, Robert Zietse, Hedwig M. A. D'Agnolo, Mahdi Salih, Folkert W. Visser, Edwin M. Spithoven, Hans de Fijter, Jack F.M. Wetzels |
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| Přispěvatelé: | Internal Medicine, Cardiovascular Centre (CVC), Groningen Kidney Center (GKC) |
| Rok vydání: | 2017 |
| Předmět: |
Male
030232 urology & nephrology Kidney Lanreotide Gastroenterology chemistry.chemical_compound 0302 clinical medicine QUALITY-OF-LIFE Stage (cooking) Pain Measurement LANREOTIDE Polycystic liver disease Organ Size Middle Aged Polycystic Kidney Autosomal Dominant Magnetic Resonance Imaging medicine.anatomical_structure Liver Nephrology Population study Female 030211 gastroenterology & hepatology Glomerular Filtration Rate Adult medicine.medical_specialty Autosomal dominant polycystic kidney disease Renal function Pain Total kidney liver volume Kidney Volume DIAGNOSIS Models Biological Gastrointestinal symptoms CLINICAL-TRIAL 03 medical and health sciences Internal medicine medicine MANAGEMENT Humans ADPKD business.industry urogenital system SOMATOSTATIN medicine.disease Abdominal Pain Endocrinology Renal disorders Radboud Institute for Molecular Life Sciences [Radboudumc 11] chemistry Renal disorders Radboud Institute for Health Sciences [Radboudumc 11] Deglutition Disorders business |
| Zdroj: | American Journal of Nephrology, 46, 3, pp. 239-248 American Journal of Nephrology, 46(3), 239-248. Karger American Journal of Nephrology, 46(3), 239-248. KARGER American Journal of Nephrology, 46, 239-248 American Journal of Nephrology, 46(3), 239-248 |
| ISSN: | 0250-8095 |
| Popis: | Background: There is an ongoing debate if and how kidney and liver volume are associated with pain and gastrointestinal (GI) symptoms in autosomal dominant polycystic kidney disease (ADPKD) patients. Since both kidney and liver volume could interact, we investigated whether combined total kidney and liver volume had stronger associations with ADPKD-related pain and GI symptoms than the volumes of the organs separately. Methods: We used baseline data from the DIPAK-1 study, which included ADPKD patients with an estimated glomerular filtration rate (eGFR) between 30 and 60 mL/min/1.73 m2. MR imaging was performed to measure height-adjusted total kidney volume (hTKV), height-adjusted total liver volume (hTLV) and the combination of both (height-adjusted total kidney liver volume [hTKLV]). Results: Three hundred nine ADPKD patients were included with a mean age of 48 ± 7 years, 53% female, eGFR 50 ± 11 mL/min/1.73 m2 and median hTKV, hTLV and hTKLV of 1,095 (758-1,669), 1,173 (994-1,523) and 2,496 (1,972-3,352) mL/m, respectively. ADPKD-related pain and GI symptoms were present in, respectively, 27.5 and 61.2% of patients. Gender was no effect modifier in the association between kidney and/or liver volume, and symptom burden, indicating that all models could be tested in the overall study population. hTKLV and hTLV were significantly associated with pain and GI symptoms, whereas hTKV was not. Model testing revealed that the associations of pain and GI symptoms with hTKLV were significantly stronger than with hTKV (p = 0.04 and p = 0.04, respectively) but not when compared to hTLV (p = 0.2 and p = 0.5, respectively). Conclusions: This study indicates that combined kidney and liver volume was associated with the presence and severity of pain and GI symptoms in ADPKD, with a more prominent role for hTLV than for hTKV. |
| Databáze: | OpenAIRE |
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