Uric acid in major depressive and anxiety disorders
| Autor: | Catherine N. Black, Peter G. Scheffer, Harold Snieder, Brenda W.J.H. Penninx, Mariska Bot |
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| Přispěvatelé: | Life Course Epidemiology (LCE), Psychiatry, APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Laboratory Medicine, APH - Digital Health |
| Rok vydání: | 2018 |
| Předmět: |
Male
Beck Anxiety Inventory DISEASE chemistry.chemical_compound 0302 clinical medicine Surveys and Questionnaires ANTIOXIDANT Netherlands METABOLIC SYNDROME HYPOTHESIS BIPOLAR DISORDER ASSOCIATION Middle Aged Anxiety Disorders Antidepressive Agents Psychiatry and Mental health Clinical Psychology Anxiety disorder Antidepressant Major depressive disorder Anxiety Female medicine.symptom Psychopathology Adult medicine.medical_specialty 03 medical and health sciences Internal medicine medicine Humans Bipolar disorder Psychiatry Life Style METAANALYSIS ALLOPURINOL Depressive Disorder Major business.industry medicine.disease 030227 psychiatry Cross-Sectional Studies PSYCHOMETRIC PROPERTIES chemistry Oxidative stress Uric acid Self Report business 030217 neurology & neurosurgery |
| Zdroj: | Black, C N, Bot, M, Scheffer, P G, Snieder, H & Penninx, B W J H 2018, ' Uric acid in major depressive and anxiety disorders ', Journal of Affective Disorders, vol. 225, pp. 684-690 . https://doi.org/10.1016/j.jad.2017.09.003 Journal of Affective Disorders, 225, 684-690. ELSEVIER SCIENCE BV Journal of Affective Disorders, 225, 684-690. Elsevier |
| ISSN: | 0165-0327 |
| DOI: | 10.1016/j.jad.2017.09.003 |
| Popis: | Background: Uric acid has neuroprotective effects, owing to its antioxidant properties. Lowered antioxidant capacity, causing increased oxidative stress, may be involved in affective disorders and might be altered by antidepressants. This study investigated the association of plasma uric acid, the greatest contributor to blood antioxidant capacity, with major depressive disorder (MDD) and anxiety disorders.Methods: Data were from the Netherlands Study of Depression and Anxiety including patients with current (N = 1648), remitted (N = 609) MDD and/or anxiety disorders (of which N = 710 antidepressant users) and 618 controls. Diagnoses were established with the Composite International Diagnostic Interview. Symptom severity was assessed with the Inventory of Depressive Symptoms-Self Report, Beck Anxiety Inventory and Fear Questionnaire. Uric acid was measured in plasma. Analyses were adjusted for sociodemographic, health and lifestyle variables.Results: Plasma uric acid adjusted mean levels were lower in current MDD and/or anxiety disorder(s) (289 mu mol/l) compared to remitted disorders (298 mu mol/l, p Limitations: Limitations include the lack of data on dietary intake which could be a potential confounding factor. From these cross-sectional findings, the association between uric acid and psychopathology cannot be inferred to be causal.Conclusion: This large scale study finds plasma uric acid levels are lower in current, but not remitted, MDD and/or anxiety disorders, according to a dose-response gradient. This suggests the involvement of decreased antioxidant status in affective disorders, and points to their potential as an avenue for treatment. |
| Databáze: | OpenAIRE |
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