Nitric oxide sensitive fluorescent polymeric hydrogels showing negligible interference by dehydroascorbic acid
| Autor: | M. Isabel Burguete, Francisco Galindo, Víctor Fabregat, M. Angeles Izquierdo, Santiago V. Luis |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Materials science
Polymers and Plastics dehydroascorbic acid Organic Chemistry Inorganic chemistry General Physics and Astronomy New materials Methacrylate Fluorescence Nitric oxide Matrix (chemical analysis) chemistry.chemical_compound fluorescence sensing chemistry nitric oxide Self-healing hydrogels Materials Chemistry Molecule Dehydroascorbic acid probes polymeric hydrogels Nuclear chemistry |
| Zdroj: | European Polymer Journal. 55:108-113 |
| ISSN: | 0014-3057 |
| DOI: | 10.1016/j.eurpolymj.2014.03.027 |
| Popis: | A series of nitric oxide (NO) sensitive polymeric hydrogels have been synthesized and their properties described. The new materials are based on a poly(2-hydroxyethyl methacrylate) matrix entrapping the DAF-FM (4-amino-5-methylamino-2′,7′-difluorofluorescein) fluorescent probe. Some of the developed materials show sensitivities in the range ca. 50–75 nM towards NO dissolved in aerated phosphate buffer (PBS), being nitrous anhydride the reactive species under such conditions. Remarkably, the sensitivity of the fluorescent polymers is not influenced by dehydroascorbic acid, a molecule of biological importance, which has been reported to be a common interfering species capable to react with well known probes for NO. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect