Modulation of human T lymphocyte rosette formation by autonomic agonists and cyclic nucleotides
| Autor: | Zarina Goel, Israel Siegel, Michael H. Grieco |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Adenosine monophosphate
Atropine medicine.medical_specialty Adrenergic receptor T-Lymphocytes Immunology Propranolol chemistry.chemical_compound Phenylephrine Phentolamine Internal medicine Guanosine monophosphate medicine Cyclic AMP Immunology and Allergy Humans Receptor Cyclic GMP Isoproterenol T lymphocyte Immune Adherence Reaction Endocrinology chemistry Carbachol medicine.drug Histamine |
| Zdroj: | The Journal of allergy and clinical immunology. 58(1 PT. 2) |
| ISSN: | 0091-6749 |
| Popis: | Early rosette formation by T lymphocytes appears to be modulated by cyclic nucleotides. Dibutyryl cyclic 3′,5′ adenosine monophosphate (cyclic AMP) 10 −2 M inhibited E rosette formation up to 83%, while 10 −6 M 8-bromo-cyclic guanosine monophosphate (cyclic GMP) increased rosette formation maximally to 67.4% with less pronounced effect at increased concentrations. T lymphocyte receptors for beta adrenergic, alpha adrenergic, and muscarinic cholinergic agonists appear to influence rosette formation. Isoproterenol 10 −2 M induced 67.3% inhibition, while phenylephrine 10 −5 M and carbamylcholine 10 −4 M were associated with enhanced rosette formation of 67.2% and 57.8%, respectively. Selective blockade with propranolol, phentolamine, and atropine indicated the presence of separate receptor sites. The lack of effect of histamine at concentrations of 10 −3 M and above suggests the absence of specific receptors on peripheral human T lymphocytes. |
| Databáze: | OpenAIRE |
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