Three-component reaction and organocatalysis in one : synthesis of densely substituted 4-aminochromanes
| Autor: | Jan Svĕtlík, Nada Prónayová, Dariusz Cież, Vladimir Frecer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry Component (thermodynamics) Organic Chemistry 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences Catalysis Cascade reaction chemistry Organocatalysis Drug Discovery Organic chemistry Stereoselectivity Alkyl Acetoacetates |
| Popis: | Cyclocondensation of salicylaldehydes with alkyl acetoacetates and 2-aminobenzothiazoles or 2-amino-thiadiazole/thiazoles under l -proline catalysis gives 4-hetarylamino substituted chromanecarboxylate derivatives. The mechanism involving the Mannich/hemiketalization cascade reaction and the observed stereoselectivity of the three component process are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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