Fever Induced byEscherichia colior Intrahypothalamic Prostaglandin E2Enhances Interferon-γ Synthesis
| Autor: | R.S. Elizondo, James F. Downing, Milton W. Taylor, K.A. Wei, E. Lundgren |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Fever Lymphocyte Immunology Population Hypothalamus Stimulation Biology medicine.disease_cause Antiviral Agents Peripheral blood mononuclear cell Dinoprostone Injections Interferon-gamma Virology Internal medicine medicine Animals Prostaglandin E2 education Escherichia coli Escherichia coli Infections education.field_of_study Macaca mulatta Peripheral Endocrinology medicine.anatomical_structure medicine.drug |
| Zdroj: | Journal of Interferon Research. 10:425-433 |
| ISSN: | 0197-8357 |
| DOI: | 10.1089/jir.1990.10.425 |
| Popis: | We previously showed that hyperthermia induced in rhesus monkeys (Macaca mulatta) by forced passive heating "primes" the peripheral lymphocyte population for increased synthesis of interferon-gamma (IFN-gamma). It was not clear whether these data could be extrapolated to the physiological response in naturally occurring fever. Therefore, in the current experiments, the temperature of rhesus monkeys was raised either by systemic injection of killed Escherichia coli or by intrahypothalamic administration of prostaglandin E2. Mononuclear cells collected subsequently from such monkeys produced more IFN-gamma in response to stimulation with mitogens than cells from control monkeys. Direct administration of IFN-alpha, -beta, or -gamma to the hypothalamus did not affect the body temperature of rhesus monkeys. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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