Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms
| Autor: | Lu Ziwen, Yi-Hang Wu, Zhigang Tu, Dongsheng Shang, Mengchen Ji, Hanqing Liu, Han Xu, Lipeng Qiu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Carcinoma Hepatocellular Biology 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences 0302 clinical medicine Circular RNA Cell Line Tumor Gene expression medicine Biomarkers Tumor Diagnostic biomarker Humans Neoplasm Invasiveness General Pharmacology Toxicology and Pharmaceutics Survival rate Cell growth Liver Neoplasms General Medicine RNA Circular medicine.disease Prognosis digestive system diseases MicroRNAs 030104 developmental biology Potential biomarkers Hepatocellular carcinoma Cancer research Disease Progression RNA |
| Zdroj: | Life sciences. 231 |
| ISSN: | 1879-0631 |
| Popis: | Hepatocellular carcinoma (HCC), a leading cause of cancer-related death with high invasive and metastatic potential, has a low survival rate. To improve the survival and quality of life in HCC patients, it is urgently needed to explore novel biomarkers for early diagnosis and prognosis of HCC, as well as therapeutic strategies. Circular RNAs (circRNAs) are a class of highly conserved, stable and abundant non-coding RNAs (ncRNAs) that can regulate gene expression at transcriptional or post-transcriptional levels. Recently, some circRNAs are identified to be potential biomarkers for HCC diagnosis and prognosis. Furthermore, some circRNAs are found to play oncogenic or suppressive roles in HCC progression by regulating various biological processes, including cell proliferation, migration, invasion and metastasis, epithelial-mesenchymal transition (EMT), as well as apoptosis. In this review, we summarize recent findings of deregulated circRNAs, their functions and molecular mechanisms in HCC, and discuss their potential roles as diagnostic biomarkers, prognostic biomarkers, as well as therapeutic targets for HCC. |
| Databáze: | OpenAIRE |
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