Arc regulates experience-dependent persistent firing patterns in frontal cortex
| Autor: | Vania Y. Cao, Ming Ren, Kuan Hong Wang, Husseini K. Manji, Yizhou Ye |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Green Fluorescent Proteins
Action Potentials Prefrontal Cortex Nerve Tissue Proteins Biology Bicuculline GABA Antagonists Mice Neuroplasticity medicine Animals Learning Receptors AMPA Prefrontal cortex Postural Balance Arc (protein) Neuronal Plasticity General Neuroscience Cell Membrane Glutamate receptor Excitatory Postsynaptic Potentials Articles GABA receptor antagonist Electrophysiological Phenomena Mice Inbred C57BL Cytoskeletal Proteins nervous system Motor Skills Excitatory postsynaptic potential NMDA receptor Neuroscience medicine.drug |
| Zdroj: | The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(19) |
| ISSN: | 1529-2401 |
| Popis: | The brain encodes information about past experience in specific populations of neurons that communicate with one another by firing action potentials. Studies of experience-dependent neural plasticity have largely focused on individual synaptic changes in response to neuronal input. Indicative of the neuronal output transmitted to downstream neurons, persistent firing patterns are affected by prior experience in selective neuronal populations. However, little is known about the molecular and cellular mechanisms by which experience-related persistent firing patterns are regulated in specific neuronal populations. Using frontal cortical slices prepared from transgenic mice carrying a fluorescent reporter ofArcgene expression, this study investigates how behavioral experience and the activity-regulatedArcgene affect patterns of neuronal firing. We found that motor training increases Arc expression in subsets of excitatory neurons. Those neurons exhibit persistent firing in contrast to Arc-negative neurons from the same mice or neurons from the untrained mice. Furthermore, in mice carrying genetic deletion ofArc, the frontal cortical circuitry is still in place to initiate experience-dependent gene expression, but the level of persistent firing thereafter is diminished. Finally, our results showed that the emergence of persistent activity is associated with Arc-dependent changes in the function of NMDA-type glutamate receptors, rather than changes in AMPA-type receptors or membrane excitability. Our findings therefore reveal an Arc-dependent molecular pathway by which gene–experience interaction regulates the emergence of persistent firing patterns in specific neuronal populations. |
| Databáze: | OpenAIRE |
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